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The Chronic Toxic Effects of Perfluortridecanoate Acid (PFTriDA) on Medaka

Author: YuYanYan
Tutor: LiuDaiChengï¼›HuJianYing
School: Shandong Normal University
Course: Of Food Science
Keywords: Perfluoro compound Perfluorinated 13 acid Organ distribution Bioconcentration Medaka fish Liver toxicity Reproductive toxicity Endocrine disruptors
CLC: X503.225
Type: Master's thesis
Year: 2011
Downloads: 130
Quote: 1
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Abstract


Perfluoro compound (Perfluorinated compounds PFCs), is a novel fluorine-containing energetic CF covalent bond of persistent organic pollutants (Persistene Organic Pollutants, POPs), in the environment caused by pollution and toxic effects in vivo by the a high degree of attention. But so far, PFCs substances more focused on PFOS and PFOA both classic material. Perfluorinated 13 acid (Perfluorotridecanoate Acid, PFTriDA) is the perfluorinated compounds in a long chain perfluorinated carboxylic acids, in recent years been widely detected in the environment and in vivo, but their environmental behavior, bioaccumulation and toxicity The role of the lack of appropriate knowledge. In this thesis, PFTriDA as the research object, as the experimental animal model organisms Japanese medaka fish, and completed PFTriDA ecological risk assessment based on the end of the toxic effects from a macro to micro gene expression changes, multi-level system of the PFTriDA chronic toxic effects. The main results are as follows: (1) the the medaka fish long-term exposure to different concentrations of PFTriDA after organ distribution and enrichment factor. The results showed that the highest organ of the concentration of PFTriDA enrichment gonads, followed by eggs, liver, the lowest concentration of organizations corpse, in addition to the gonads, the organ distribution consistent with the wild Chinese sturgeon. Also found that the male body organs the PFTriDA the content is higher than females in the same exposure the mechanism model calculations show that high maternal and child transfer coefficient is caused by the possible causes of the male and female differences. The exposure concentrations PFTriDA increased, the same organ in fish bioconcentration factor (BCF) show a downward trend. (2) to carry out the toxic effects of experimental PFTriDA entire life cycle of the medaka fish. The study PFTriDA long-term exposure to low doses of growth and development of the medaka fish, the reproductive capacity of the F1 embryo development through the entire life cycle of the F0 generation medaka fish exposed to the ambient concentration levels PFTriDA. The results show that the PFTriDA long-term exposure to significantly stimulate the female liver, gonads growth, an inverted \With the exposure concentration PFTriDA increase, medaka fish spawning inhibited to some extent, but the highest dose group is not the strongest inhibition. In In addition, PFTriDA long-term exposure to medaka fish fertilization rate, embryo hatching rate and hatching time F1 generation had no significant effect, but in the exposed group in the F1 generation embryo serious deformity. (3) Based on the macro observation on the basis of further medaka fish liver toxic effects at the molecular level to explore PFTriDA exposure. The results showed that PFTriDA long-term exposure to low concentrations of medaka fish did not cause significant liver pathology injury. In addition, PFTriDA exposed to the oxidative damage generated by the male than the female a little obvious, but not significant influence on the expression of the liver fatty acid metabolism-related genes. P53 expression level rise can lead to apoptosis and fetal malformation. The toxic effects of PFTriDA obvious may be designed in this paper PFTriDA exposed to lower concentrations. (4) from the molecular level to explore PFTriDA exposure interference effects on the endocrine system of the medaka fish, the main research gonadal axis in the endocrine system and thyroid axis interference and initial interpretation of PFTriDA of exposed medaka fish breeding capability and endocrine disruptors the mechanism. The experimental results found, PFTriDA long-term low-concentration exposure does not cause sensitive marker substance VTG the significant change, gonadal steroid hormone synthesis pathway from the rate-limiting role of enzymes StAR and CYP11A and with sex hormone synthesis of the key role of the enzyme HSD-17beta and The Cyp19 express has a significant inhibitory effect, indicating that PFTriDA long-term exposure to low concentrations play a significant inhibitory effect on medaka gonadal axis. PFTriDA exposure to low concentrations can induce the male medaka thyroid hormone released from the follicles, but was inhibited at high concentrations. The other PFTriDA exposure can inhibit the the glucoside role of thyroid hormone in the liver. Detection means comprehensive, can not determine PFTriDA long-term exposure to low concentrations of the medaka fish thyroid axis, which also need further refinement.

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CLC: > Environmental science, safety science > Environmental pollution and its prevention > General issues > The hazards of environmental pollution > Biological hazards > Animal > Fish,aquatic
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