Dissertation > Excellent graduate degree dissertation topics show

The Effect of Royal Jelly on Learning and Memory Ability and Anti-aging of Aging Rats

Author: PengYouRui
Tutor: ZhongFangXu
School: Wuhan Polytechnic University
Course: Microbial and Biochemical Pharmacy
Keywords: Royal jelly D-galactose Aging model Morris water maze Learning and memory ability anti-aging activity
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 76
Quote: 0
Read: Download Dissertation

Abstract


This paper takes adult SD rats as experimental material.The sub-acutely aging rats were made by injecting 2.5% D-galactose solution into the rats’abdominal cavity continuously,last 45 days. After it, administered intragastrically with different concentrations of royal jelly for 90 days. The learning and memory ability of rats in each group were detected with Morris water maze.The monoamine transmitter contents such as norepinephrine and dopamine in the brain were detected with Fluorescence spectrophotometer in order to observe the effect of royal jelly on learning and memory ability of aging rats .Then detect the variation of the activity of SOD and the content of MDA in each rats, blood serum and lung and spleen, in order to observe the effect of royal jelly on anti-aging activity.The results show that the learning and memory ability of aging rats dropped significantly compared with normal rats. The average latent period of the model group extended distinctly, the latency prolonged from 15.52s to 21.62s. In the probe test, the number of traversing originally platform dropped obviously, the number dropped from 7.5 to 4.25 (P﹤0.05) ,the types of swimming track of the model group changed remarkably. The NE, DA contents in the brain of aging rats decreased significantly,the activity of SOD also decreased significantly, the content of MDA rising markedly(P﹤0.05). we can indicate that the sub-acutely aging rats was successfully manufactured.While the learning and memory ability of royal jelly rats improved significantly compared with aging rats, The average latent period shortened obviously from 21.62s to 14.34s(P﹤0.01), In the probe test, the number of traversing originally platform improved obviously, the number improved from 4.25 to 8.22 (P﹤0.01).The NE, DA contents in the brain increased from 196.87ng/g、160.75ng/g to 314.62ng/g、251.00ng/g respectively (P﹤0.01). The activity of SOD enhanced, the contents of MDA dropped obviously in royal jelly rats, blood serum and lung and spleen.These results indicate that royal jelly can improve spatial learning and memory ability of aging rats and content of monoamine neurotransmitters, SOD activity, can reduce the MDA contents. It can inferred that royal jelly can regulate the metabolized of monoamine transmitter effectively and anti-aging, improve the learning and memory ability.

Related Dissertations

  1. Gene Cloning and Expression Profiling of Ascorbic Acid Biosynthesis in Non-Heading Chinese Cabbage and Functional Analysis of BcPMI2,S634.3
  2. The Effects of High Protein Feeding on the Brain Development of IUGR Rats,R714.5
  3. Effect and Mechanism of Walnut Oil, Perilla Oil,α-linolenic Acid and Linoleic Acid Supplementation on Rats Spatial Learning and Memory Ability,R151
  4. Galactosylated Chitosan Grafted Polycarprolactone Nanoparticles Used as Liver Drug Delivery,R943
  5. Anti-amnesic Activity of Neferine, Isoliensinine and Liensinine,R285
  6. Surface Modification of Poly (ε-caprolactone)s and Its Influence on Cell Behaviour,R318.08
  7. The Study of the Role for Hes1 in Adult Neurogenesis after Hippocampus Injury,R651.1
  8. The Association between Androgen Deficiency, Obesity and Lipid Metabolism Genes in Males,R589.2
  9. A549 cells and Hep-2 cell surface sugar chains type identification and its characteristics combined with the H5N1 avian influenza virus,S852.65
  10. Mitochondrial Dysfunction in the Multiplicity Rodent Model for Alzheimer’s Disease Induced by Long-term D-galactose Injection Combined with Ovariectomy,R749.16
  11. Induction of Klotho Gene Expression by Natural Product Compounds and the Anti-aging Analysis,R285
  12. Experimental Study of the Antarctic Krill Oil on the Serum Lipids and Antioxidation Ability and Memory Ability,S917.4
  13. Construction of Actinidia Latifoia Merr.Galdh Plant Expression Vector and Its Transformation into Tomato,S663.4
  14. Dobesilate galactose cataract in rats Inhibitory effect of,R965
  15. Study on Synthesis and Antitumor Activity of Targeted Drug Delivery System for Combretastatin A4 Using Galactose Units as the Carrier,R96
  16. Effects of Different Load Swimming on Nonenzymatic Glycosylation in Aged Mice Induced by D-galactose,R87
  17. Expression of α1, 3 Gal Epitopes at the Cell Surface Inhibits the Tumorigenic Properties of Hepatocellular Carcinoma Cell Line Huh7,R735.7
  18. Synthesis and Antimicrobial Activity of Fumarate Based Sugar Easters,TS201.3
  19. Study on the Anti-Oxidation and Immunoregulatory Effects of Ganoderma Spore Oil on Mice,R285.5
  20. Effects of Soybean Phospholipid on Learning and Memory Related Genes and Abilities of Antioxidation,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile