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Expression and Clinical Significance of CTGF、VEGF and HIF-1α in Pancreatic Cancer

Author: ZhengGang
Tutor: LiuJianSheng
School: Shanxi Medical
Course: Surgery
Keywords: CTGF VEGF HIF-1α Immunohistochemical Tumor microenvironment Pancreatic cancer Hypoxia
CLC: R735.9
Type: Master's thesis
Year: 2011
Downloads: 55
Quote: 0
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Abstract


Objective：To investigate the expressions of CTGF, VEGF, HIF-1αand the relationshipsbetween them and various clinical pathological characteristics in human pancreatic cancer.Methods：To investigate the expressions of CTGF, VEGF and HIF-1αin tumor issues from 46radically resected specimens of pancreatic cancer and 10 normal pancreatic tissues by Envisiontwo-step immunohistochemical staining.Results: CTGF, VEGF and HIF-1αin pancreatic cancer tissues are significantly higher thanthat in normal pancreatic tissues（P<0．01）. CTGF：45.7％（21/46）、VEGF：71.7%（33/46）、HIF-1α：76.1%(35/46).The Positive rate of CTGF was closely related to the age, clinicalstage,pathologic stage grading and lymph node metastasis（P<0.05）.The Positive rates of VEGFwas closely related to the clinical stage（P<0.05）,and other tumor biological behaviours isirrelevant. The Positive rates of HIF-1αwas closely related to the clinical stage（P<0.05）,andirrelevant to other tumor biological behaviours .The Spearman Correlation coefficients ofCTGF and VEGF : r=0.575（P<0.05）.The Spearman Correlation coefficients of CTGF andHIF-1α: r=0.483（P<0.05）.The Spearman Correlation coefficients of VEGF and HIF-1α:r=0.082（P<0.05）. Positive correlations were mutually found between each two of the three(P<0.01).Conclusion: Up-regulated expressions of CTGF, VEGF and HIF-1αexist in human pancreaticcancer. CTGF,VEGF and HIF-1αplay an important role in the occurrence and developmentprocess of the pancreatic cancer in the Hypoxia microenvironment.The positive rate of CTGFwas closely related to the age, clinical stage,pathologic stage grading and lymph nodemetastasis.The positive rates of VEGF and HIF-1αwere closely related to the clinical stage,andother tumor biological behaviours is irrelevant. The clinical pathological detectability of CTGFrange more elements than VEGF and HIF-1α.Detecting together with CTGF, VEGF and HIF-1αin pancreatic cancer ,could provide more advises for prognosis and new clinical treatmentapproach.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Pancreatic tumors
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