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Objective: To analyze the non-small cell lung cancer patients with advanced GP program differences in blood sugar and interfere with its trend before and after three cycles of chemotherapy . Methods : 44 patients with advanced non - small cell lung cancer into groups , divided according to blood glucose normal blood glucose and blood sugar group : normal blood glucose directly in 32 patients with 3 cycles of chemotherapy GP program , the hyperglycemia group of 12 patients be then after the intervention of diet, exercise and insulin the GP regimen for 3 cycles . Chemotherapy before and after the line blood count , biochemistry full set , C-reactive protein ( CRP ) , oral glucose tolerance test , C peptide and insulin release test . The diagnosis of diabetes who use insulin intervention with continuous glucose monitoring system to monitor and guide therapy until the blood sugar normal . Results: 1. Before chemotherapy, blood sugar normal after the GP regimen chemotherapy after 3 cycles in 25% ( 8 / 32 ) of patients with elevated blood sugar , half of the patients into diabetic patients after chemotherapy in patients with impaired glucose regulation . The hyperglycemia after chemotherapy and blood sugar normal aspartate aminotransferase (AST) and C - reactive protein , a significant difference ( P lt; 0.05 ) ; C-peptide and insulin release test showed that after chemotherapy , blood sugar normal postprandial 1h insulin and C-peptide is the hors d' 5.9 times and 8 times , 2h fell to fasting levels . Impaired fasting plasma glucose regulation, insulin and C-peptide values ??close to normal blood glucose , 2h reached the highest peak delayed , can not be restored to fasting levels . Compared to the diabetic group with normal blood glucose excretion curve of the lower level , although fasting near normal , but the peak delayed and significantly reduce fasting 2.8 times and 2.4 times . 3 . Diabetics control blood sugar caused by chemotherapy using CGMS monitoring of blood glucose can help adjust blood sugar , especially to prevent the occurrence of hypoglycemia . Conclusion : 1.GP program can cause part of the non-small cell lung cancer patients with advanced impaired glucose metabolism and elevated blood glucose , AST , CRP, abnormal and poor islet function were more prone to blood sugar . CGMS monitoring of blood glucose can well guide the treatment of chemotherapy of lung cancer caused by high blood sugar , and to detect asymptomatic hypoglycemia .
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