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Polycyclic aromatic hydrocarbons (PAHs) exposure during pregnancy on neonatal neurobehavioral its biomarker research

Author: LiXiaoHua
Tutor: NiuQiao；NieJiSheng
School: Shanxi Medical
Course: Occupational and Environmental Health
Keywords: Polycyclic aromatic hydrocarbons Urinary 1 - hydroxypyrene NBNA BDNF
CLC: R722.1
Type: Master's thesis
Year: 2011
Downloads: 44
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Abstract

Objective: To investigate pregnancy exposure to polycyclic aromatic hydrocarbons (PAHs) and neonatal neurobehavioral development relationship, brain-derived neurotrophic factor whether specific biomarkers as polycyclic aromatic hydrocarbons exposure during pregnancy on neonatal neurobehavioral impact. Method: high performance liquid chromatography (HPLC) determination of Taiyuan, Changzhi cooperative hospital air PAHs, High Performance Liquid Chromatography childbirth cooperation in the local hospital in November 2009 - May and signed informed consent 297 1 - hydroxypyrene content, application newborns 20 neurobehavioral Inspection Act (NBNA) the determination of the two newborn neurobehavioral development, using ELISA kit for determination of cord blood plasma brain-derived neurotrophic factor in the urine of pregnant women (BDNF) content. Comparison of Taiyuan and Changzhi PAHs in air, 1 - hydroxypyrene content in the urine of pregnant women, newborn neurobehavioral developmental scores, cord blood plasma brain-derived neurotrophic factor content and application of the multiple regression analysis of various indicators factor. Results: 1. Changzhi, Taiyuan is a coal-fired pollution, Taiyuan air PAHs than Changzhi, the two air pyrene, benzo [a] anthracene, Qu, benzo [a] pyrene, two benzanthracene was statistically different. The average mass concentration of PM10 in Taiyuan cooperation Hospital 409.782μg / m ~ 3, the the 9 PAHs detected 411.106ng / m ~~, the concentration of B [a] P 0.025μg / m ~~ 3 is National neighborhood atmosphere of B [a] P concentration limits (0.01μg / m ~ 3) 2.46 times. Changzhi cooperation Hospital PM10 average concentration for 452.119μg / m ~ 3, measured 9 PAHs 289.166ng / m ~ 3, the concentration of B [a] P 0.017μg / m ~ 3, the state residents District atmospheric B [a] P concentration limit of 1.72 times. 2 Taiyuan urine of pregnant women 1 - hydroxypyrene content (median 1.140μg/mmolCr, P25 0.457μg/mmolCr P75 for 2.678μg/mmolCr) higher than in the urine of pregnant women Changzhi 1 - hydroxypyrene content (median number 0.761μg/mmolCr, P25 0.133μg/mmolCr, P75 for 2.095μg/mmolCr), the difference was statistically significant. 1 - hydroxypyrene content in the urine of pregnant women with the air PAHs, pregnancy, parity was positively correlated; maternal education level, the number of months of pregnancy was negatively correlated. Taiyuan 153 newborn neurobehavioral median total score of 38 points, the highest score of 40 points, the lowest score of 34 points, including four less than the normal standard (≦ 35 points); Changzhi 144 newborns neurobehavioral median total score of 39 points, the highest score of 40 points, the lowest score of 37 points, all standard newborn. The Taiyuan neonatal the NBNA score, incapacitated score, passive muscle tension score, scores and general valuation score below Changzhi neonatal active muscle tension, and the difference was statistically significant. The NBNA Total number of pregnant women was positively correlated; 1 - hydroxypyrene values, pregnancy calcium deficiency, pregnancy cesarean section was negatively correlated with the urine of pregnant women. Neonatal behavioral ability to score with pregnant women spouse's education level was positively correlated; 1 - hydroxypyrene values, I am drinking and pregnancy intake of dairy products was negatively correlated with the urine of pregnant women. Neonatal passive muscle tension score the contraception before pregnancy was positively correlated; urine of pregnant women - hydroxypyrene values, poor maternal health status, exposure to toxic substances after pregnancy was negatively correlated. Neonatal active muscle tension score with pregnant women, pregnancy, parity was positively correlated; nervous system disease was negatively correlated with the pregnant woman or the spouse of the parents. Neonatal primitive reflexes score was positively correlated with intake of fruits and vegetables during pregnancy; - hydroxypyrene values ??were negatively correlated with the pregnancy, cesarean section, the urine of pregnant women. Neonatal general the valuation score was positively correlated with 1'apgar ratings; 1 - hydroxypyrene values, this pregnancy cesarean section was negatively correlated with the urine of pregnant women. Urinary 1 - hydroxypyrene content NBNA score correlation (R-2 = 0.226) gt; the general valuation score correlation (R ~~ 2 = 0.068) gt; primitive reflex score correlation (R ~ 2 = 0.054) gt; the capacity score correlation (R ~~ 2 = 0.045) gt; the scoring with passive muscle tension correlation (R ~~ 2 = 0.032). Taiyuan neonatal cord blood plasma brain-derived neurotrophic factor levels in the median the 3.447ng/mL, interquartile range 3.363ng/mL; Changzhi City in newborn cord blood plasma brain-derived neurotrophic The factor content median 2.278ng/mL, interquartile range 2.318ng/mL. Higher than the brain-derived neurotrophic factor content in the umbilical cord blood of newborns Taiyuan the newborn Changzhi City, the difference was statistically significant. Neonatal umbilical cord plasma brain-derived neurotrophic factor content with NBNA score, passive muscle tension score, active muscle tension score the General Valuation negatively related. Passive muscle tension score> Total NBNA correlation> correlation score and active muscle tension> Average Estimated score. Content of brain-derived nutritional factors and pregnancy nausea, vomiting, seafood intake, dairy intake, urine of pregnant women 1 - hydroxypyrene values ??were positively correlated; regular consumption of animal food was negatively correlated with pre-pregnancy. Conclusion: the type of polycyclic aromatic hydrocarbons pollution in Taiyuan, Changzhi, Taiyuan study of polycyclic aromatic hydrocarbons, with coal-burning pollution exposure is higher than the study of Changzhi City. 2. Pregnancy exposure to polycyclic aromatic hydrocarbons (PAHs) capacity development of newborn neurobehavioral adverse effects. 3. Brain-derived neurotrophic factor as pregnancy PAH Exposure newborn neurobehavioral impact of specific biomarkers, remains to be further studied.

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