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Study on the Relationship between Hydyogen Sulfide Concentration and Cerebral Trauma

Author: BianYanFeng
Tutor: YangXiaoMing
School: Shanxi Medical
Course: Emergency Medicine
Keywords: Traumatic brain injury Hydrogen sulfide Spectrophotometry
CLC: R651.1
Type: Master's thesis
Year: 2011
Downloads: 25
Quote: 0
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Abstract


Objective: To investigate the relationship of brain trauma serum H2S concentration and brain injury degree . Methods : SD rats were randomly divided into control group of surgical control and traumatic brain injury , traumatic brain injury group divided into mild , moderate and three sub-groups , each group of six rats . Spectrophotometric determination of serum concentration of H2S in rats and serum H2S concentration differences and serum concentration of H2S with traumatic brain injury degree of relationship between the analysis group . Results: the average concentration of the control group, serum H2S ( 14.87 ± 5.12 ) μmol / L , sham-operated rats serum concentration of H2S average ( 16.58 ± 6.27 ) μmol / L in serum concentration of H2S was not statistically significant ( P gt; 0.05). Sham group average serum hydrogen sulfide concentration ( 16.58 ± 6.27) μmol / L compared with the average concentration of mild traumatic brain injury in serum H2S ( 32.93 ± 6.66) μmol / L, increased by 49.6% (P lt; 0.05), The difference was statistically significant . Subgroup in traumatic brain injury , moderate injury group and the severe injury group, the average concentration of serum H2S were ( 48.34 ± 8.01) μmol / L , ( 64.15 ± 10.69 ) μmol / L , with the mild group serum H2S The average concentration ( 32.93 ± 6.66) μmol / L respectively when compared with increased 52.4% and 89.0% . (P lt; 0.05), the difference was statistically significant , severe injury group than the moderate injury group, serum H2S content increased by 32.8 % ( P lt; 0.05 ) , the difference was statistically significant . Conclusion: Acute traumatic brain injury in rats serum H2S content increases, the degree of brain parenchymal damage is heavier , more obvious elevated serum H2S content , serum H2S content has a certain practical value of the judgments of the disease and its treatment of traumatic brain injury .

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