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The Outcome Observation of Brain Injury Patients with Different APOE Isoforms Treated by Oxiracetam Injection

Author: YangJun
Tutor: YangFuBing
School: Luzhou Medical College
Course: Surgery
Keywords: Apolipoprotein E gene polymorphism Multiplex Polymerase Chain - high temperature ligase detection reaction Oxiracetam injection Traumatic brain injury GCS score MMSE score NOS-TBI score
CLC: R651.1
Type: Master's thesis
Year: 2011
Downloads: 25
Quote: 0
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Abstract


Objective : To investigate the use Oxiracetam injection treatment of the acute phase of severe head injury patients , apolipoprotein E (APOE) gene polymorphisms affect the efficacy of the drug . Methods: 78 cases of acute period , cases of severe traumatic brain injury , venous blood 2 ml of each patient , genomic DNA was extracted using the multiplex polymerase chain - high temperature ligase detection reaction (PCR-LDR) to detect the APOE gene single nucleotide polymorphism; every object within 48 hours after admission to the injection in the treatment of Oxiracetam week , during treatment, prohibit the use of other nootropics . GCS scores before and after treatment (Glasgow coma scale), MMSE score (Mini mental state examination) and NOS-TBI score (Neurological outcome scale for traumatic brain injury), to analyze the relationship between the different subtypes and therapeutic effect of the APOE gene . Results : 78 patients detected ε2 / 2 , ε3 / 3 , ￡ 4 /4 three kinds of homozygotes and ￡ 2 / ￡ 3/4 two heterozygous Not Detected ￡ 2 /4 heterozygotes ￡ 3 / 3 homozygotes highest proportion ε2 / 2 homozygotes the lowest proportion of APOE phenotype ; allele frequencies by ￡ 3 the highest , accounting for 80.13% . The ￡ 2/2 type and type ε2 / 3 together as a group , ￡ 3/4 type and ￡ 4 / 4 type together as a group , then together for comparison with the type ε3 / 3 before and after treatment in each group GCS , the MMSE score significantly improved , NOS-TBI has significantly reduced . ￡ 2/2 ￡ 2 / 3 and ￡ 3 /3 type between efficacy was no significant difference , ￡ 3/4 ε4 / 4 type with more than two groups were differences between groups . Conclusion: ① Oxiracetam injection of the acute phase of an effective treatment of severe traumatic brain injury . The ② apolipoprotein E gene polymorphism the Oxiracetam injection treatment of acute period, the effect of severe traumatic brain injury influential . ( 3 ) carrying the APOE ￡ 4 allele in patients with Oxiracetam injection treatment effect than the non- poor patients carrying the genotype . APOEε4 allele may be one of the reasons for this result .

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CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain
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