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Intervening Mechanisms of Compound Long Yan Shen San on Experimental Atherosclerosis

Author: ShiXiaoXia
Tutor: JiangWeiZhe
School: Guangxi Medical University
Course: Pharmacology
Keywords: Compound Longyanshen scattered Atherosclerosis Quail Hyperlipidemia Proliferating cell nuclear antigen Mechanism
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 35
Quote: 1
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Abstract


Objective: To establish atherosclerosis (Atherosclerosis, AS) animal models to study the compound longan participate in bulk (Compound Long Yan Shen San, CLYSS) anti-AS, and inhibition of vascular smooth muscle cells (Vascular smooth muscle cell, VSMC) proliferation aspects to explore its intervention mechanism. Methods: A high fat diet quail establish hyperlipidemia and atherosclerosis model. Take male Japanese species of quail 175 randomly divided into 7 groups: normal control group, hyperlipidemia model group, the positive control of the Medicines evening primrose oil group (10ml? Kg-1), western medicine positive control simvastatin group (6.6mg ? kg-1) and the strong medicine compound Longyanshen scattered low, medium and high dose (187.5,375.0,750.010 mg? kg-1) group. In addition to the normal control group was fed a normal diet, the other six groups were fed a high fat diet. Feeding to 12 weekend, the formation of the other six groups in addition to the control group with normal lipid caused significantly high cholesterol state. 13 weeks to give the medication, continuous gavage for 12 weeks, morning afternoon fed a high fat diet, fed with basic feed, model group and blank group diet unchanged. Determination of serum lipid indicators, including cholesterol (TC), triglyceride (TG) in the first 24 weeks of high-density lipoprotein cholesterol (HDL-Ch), low-density lipoprotein cholesterol (LDL-Ch, lipid-laden protein AI (apo-AI), apolipoprotein B (apo-B), etc.; naked eye and light microscopy histological examination of the aorta and liver of the the AS lesions and the degree of hepatic steatosis grade comparison; using immunohistochemical detection of aortic proliferating cell nuclear antigen (PCNA) expression levels in VSMC. Results: Compared with model group, the compound Longyanshen scattered treatment group significantly reduced serum TC, TG, LDL-Ch, apo-AI content elevated serum apo-B content (P lt; 0.05), and significantly lower TC, TG content in liver homogenates; 2. histopathological examination results show that, compared with model group, the compound Longyanshen scattered treatment group main arterial intimal atherosclerotic plaque lesions reduced significantly mitigate the degree of hepatic steatosis compared with the model group. 3. aortic wall PCNA measurement results show in: CLYSS group PCNA-positive cells was significantly lower than that in the untreated control group (P lt; 0.01). Conclusion: 1. the a strong drug compound longan Participation bulk have the role of regulating blood lipids; 2. Zhuang medicine the compound Longyanshen scattered the significant therapeutic effect on atherosclerosis 3. the compound Longyanshen bulk has a role to inhibit the expression of PCNA, may be one of the mechanisms of its anti-AS.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
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