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The Expression and Clinical Significance of CREB in Acute Myeloid Leukemia and Myelodysplastic Syndromes

Author: WangPeiJun
Tutor: HuangShiAng
School: Huazhong University of Science and Technology
Course: Internal Medicine
Keywords: Real-time quantitative PCR CREB acute myeloid leukemia myelodysplastic syndromes
CLC: R551.3
Type: Master's thesis
Year: 2011
Downloads: 4
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Abstract


Objective To study the expression and clinical significance of CREB mRNA in acute myeloid leukemia and myelodysplastic syndromesMethods Real-time quantitative PCR was performed to detect CREB mRNA expression in peripheral blood from 12 cases of acute myeloid leukemia (AML), 13 cases of myelodysplastic syndrome (MDS), as well as 9 cases of Non-hematologic malignancies as the controls.Results the expression levels of CREB among the three groups were statistically different(p<0.05);The expression levels of CREB mRNA in AML patients were 4.390±1.840,those in MDS patients were 1.423±0.425,Both the AML and MDS groups exhibited signifcantly higher CREB expression levels than control group (P= 0.00 and P= 0.01,respectively), the expression levels of CREB mRNA among the three groups showed an increasing trend.Conclusions CREB can act as a complementary indicator to judge condition and identify myelodysplastic syndrome and acute myeloid leukemia. The mechanism of CREB exhibited higher expression in AML and MDS is required further study.

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CLC: > Medicine, health > Internal Medicine > Blood and lymphatic system diseases > Hematopoietic diseases > Bone marrow disease
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