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In this thesis, including the two parts of the literature review and clinical research. Two of Literature Review: Summary of a major summary of Chinese medicine in metastatic breast cancer and the role of the advantages that metastatic breast cancer first detailed analysis of the positive imaginary based positive imaginary disease and its treatment, should be righting Pei this based treatment principles combined detoxify Kangliu as. Secondly, discusses aspects of the treatment of metastatic sites from the Resolution, including bone metastases, lung metastases, liver metastases election party drug experience. The third is to improve the quality of life of advanced breast cancer, mainly from improving insomnia, depression, pain, loss of appetite and other symptoms are discussed. Summary of major retrospective overview of chemotherapy for the treatment of advanced breast cancer at home and abroad. Introduces the indications for chemotherapy, metastatic breast cancer, ER, PR negative, or symptomatic visceral metastasis, or ER, PR positive endocrine therapy ineffective. Selection of methods and principles of chemotherapy drugs, MBC treatment decision making, including (1) previous drug treatment and its efficacy (2) disease-free interval (3) the efficacy of endocrine therapy (4) HER2 status (5) tumor burden (defined as the transfer treatment the patient wishes and the patient area of ??the stove number and location) menopause, age, comorbidities (including organ dysfunction), PS (6) the need to control the disease / symptoms fast, socio-economic and psychological factors (7) . Priority use of the drug program anthracycline, taxane, the antimetabolite and other microtubule inhibitor. Choice of single-agent and combination chemotherapy regimens, faster disease progression, general, tumor burden, young patients can choose the combination chemotherapy, slow disease progression, tumor burden, poor general, consider the single-agent chemotherapy in elderly patients. And targeted drug application. Clinical Research: Objective: To observe the Integrative Medicine clinical efficacy for the treatment of advanced breast cancer. Methods: January 2005 to mid-May 2011, a total of 68 cases, patients with metastatic breast cancer Friendship Hospital Integrative Medical Oncology hospitalization MAIN OUTCOME MEASURES free survival (0S), Secondary indicators of tumor progression time (TTP). Results: Integrative Medicine group of 59 people, with a median survival of 38.5 months (8-108 months), the median TTP was 15 months (4-65 months). Western medicine group, 9 patients, 0S shortest two months, the longest nine months, with a median overall survival of 5 months. Integrative group median OS and median TTP were significantly prolonged compared with the literature. Significant difference (P lt; 0.05) and a combination of Chinese and Western medicine group and western medicine group 0S. Conclusion: Integrative treatment of advanced breast cancer can prolong overall survival and prolong TTP.
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