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Exogenous fever in children pneumonia in children is a common pediatric respiratory system infection, is a traditional Chinese medicine, \This paper summarizes the Valley Xiaohong, professor of clinical diagnosis and treatment of children with exogenous fever, lung and stomach (intestinal) Tongzhi experience, children with pneumonia, for example, systematic summary of the relevant literature, there is an important correlation that pediatric pneumonia and Yangming heat. Objective: The Valley Xiaohong Professor lung and stomach Tongzhi Clinical Diagnosis and Treatment of Children Exopathogenic Hyperactivity card experience as the starting point to explore the correlation of pneumonia in children and Yangming heat to reveal Yangming heat impact on the development of children with pneumonia occurred. Methods: The paper is divided into theoretical and experimental research and clinical applications. Theoretical study: First, children with pneumonia and Yangming heat related TCM Theory, respectively, from the organs, pathogenesis, legislative prescriptions to demonstrate the correlation between the two, and to explore the physiological and pathological characteristics of children with special usually male Ming heat children with easy internal factors exogenous fever occurs. Pneumonia in children Yangming heat and Western medicine theory study, pediatric respiratory, digestive, immune system, explore their relevance. Experimental study: preparation of the Yangming integrated heat syndrome mouse model, mice were observed for signs EGG tracings established model, exploring not the same phase and Yangming heat, and by the detection of serum tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), interleukin-4 (IL-4) and TH1/TH2 level to explore Yangming plot heat syndrome impact on immune function; the nasal infection Yangming product heat syndrome small mouse (FM1) influenza virus, and replication of viral pneumonia model, detection at different phases of mouse spleen index, thymus index, serum immunoglobulin M (IgM) antibody and serum TNF-α, IFN-γ, IL- The 4 and TH1/TH2 level to explore the impact of the of Yangming accumulated heat of influenza virus infection (FM1) the incidence of pneumonia in mice and immune function. Clinical applications: a retrospective summary of the period from March 2009 to May 2010 pediatric doctor to come exogenous fever syndrome of lung and stomach plot (Yu) hot cases, analysis summed diet disloyal the Yangming plot (Yu) avid played the role to explore the root causes of Yangming heat preliminary demonstration of the influence of exogenous fever incidence in children and pneumonia in children, thus further Yangming heat related clinical basis. Results: theoretical research: lung, stomach (intestinal) physiological closely related to pathological interactions, pediatric pneumonia card case Hyperactivity the Yangming hot to promote the development of the occurrence of Hyperactivity card, known as Yangming heat, easy to incur exogenous pathogens table phase lead, Yun and fever, and eventually became the lung and Yangming disease heat syndrome, pediatric delicate organs, diet I do not know since section, easy to plot Yun heat, the body of the case the \easy to empty, easy implementation, exogenous pathogens into the lungs, Yangming heat cited evil-depth, the Evils Shun pass Yangming, through contact between the lungs, gastrointestinal's organs, meridians, qi and blood, gastrointestinal plot (Yu) hot on the smoke in the lungs, lung failure declared down cause pneumonia Asthma; Western medicine study confirmed the lung and gastrointestinal physiology, pathology closely pediatric respiratory development is not sound, imperfect defense, the morphology of the digestive organs and physiological functions were not developed, non-specific immune relatively poor, the symptoms of the respiratory and digestive symptoms often have great relevance, such as lung gastrointestinal diseases in children the concept of the proposed. Experimental research: experimental: Compared with the normal control group, model group mice EGG slow wave waveform irregular amplitude arrhythmia, showed a high frequency high amplitude, more significantly EGG changes to the model four days group; with compared to the normal control group, model 4-day group and Model 7 days, serum levels of TNF-α level than has tended to increase, but the difference was not significant (P> 0.05), model group, serum TH1/TH2 (IFN-γ / IL-4) levels, a significant difference (P <0.05). Experiment II: influenza virus infection (FM1) serum IgM antibody content: Compared with normal control group, 1 and 3 days after infection, increased model group, and simple pneumonia group increased significantly, a significant difference (P <0.01 ), food plot pneumonia group is lower than the simple pneumonia group, but the difference is not significant with (P> 0.05); the 5th day after infection, the model group, lower than the normal control group, and the food product pneumonia group were significantly lower, the difference in a very significant significantly (P 0.05), food plot pneumonia group was significantly lower than pneumonia group, a significant difference (P <0.01). Influenza virus (FM1) the mice serum TNF-α levels: 1,5 days after infection, simple pneumonia group, the food plot pneumonia group were higher than the control group, but the difference was not statistically significant (P gt; 0.05); infection 3 days, simple pneumonia group, the food plot pneumonia group were higher than the normal control group, and the food product pneumonia group increased more significantly, a significant difference (P <0.05); phases the food plot pneumonia group than in simple pneumonia group, and in 3 days after infection, increased significantly, a significant difference (P <0.05); influenza virus (FM1) serum TH1/TH2 (IFN-γ/IL-4): 1,3,5 simple pneumonia group, food plot pneumonia group were lower than the normal control group, and after infection on day 3, differences significant significantly (P <0.05), after infection, the first 5 days, food plot pneumonia group decreased significantly, the difference in a very significant with (P lt; 0.01 ); phases, the food plot pneumonia group compared with pneumonia group have a downward trend, but the differences were not significant (P> 0.05). Conclusion: Yangming heat played an important role in the occurrence and development of children with pneumonia. Yangming plot heat syndrome caused by an imbalance of the immune status, and to become of Pediatric easy exogenous possible mechanism of action, the Yangming plot heat syndrome caused by the release of the inflammatory cytokine TNF-α, but the results need to be confirmed by further studies. 3 after infection, IgM levels decreased immune imbalances, leading to the decline in body resistance to infection; viral infection caused by the body's release of TNF-α, Yangming integrated heat syndrome more significant impact, especially in the post-infection three days ; influenza virus that could cause the body's immune imbalances, especially after infection three days Yangming heat card immune imbalance aggravating trend preliminary Yangming interior heat syndrome caused by the body's immune imbalance led to its easy exogenous possible mechanism, but further studies.
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