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Study of Swine Model by Mitral Valve Replacement with Prosthetic Valve in Different Configurations

Author: HuangDong
Tutor: YangHongSheng；ZhangGuiMin
School: Kunming Medical College
Course: Surgery
Keywords: Pig Mitral valve replacement Animal models Turbulent shear stress Subvalvular
CLC: R-332
Type: Master's thesis
Year: 2011
Downloads: 16
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Abstract

Objective: To establish the animal model of porcine mitral valve replacement (MVR), to explore the key factors that affect the successful establishment of the animal model, value and operability of the evaluation model. Prosthetic valve downstream hemodynamic compare different configurations based on the merits of providing methodological foundation for further study of the relationship between artificial heart valves downstream hemodynamic and valvular its flap structure retained surgical. Method: closed colony to select Diannan miniature pig 7 establish an animal model, using the method of anesthesia cardiopulmonary bypass through the left atrial appendage mitral valve replacement approach the line retain full prosthetic structure replaced with a prosthetic valve type is divided into three groups: single leaf mechanical valve group (n = 2); bileaflet mechanical valve group (n = 3); bioprosthesis group (n = 2). Modeling based on comparative analysis of the structure and function of the heart and hemodynamic indicators combined with computer image analysis, color Doppler evaluation before and after surgery, and the different configurations prosthetic valve downstream turbulent shear stress. Results: The animal models were successfully established, the mean operative time was 175.0 ± 38.9min, average bypass time 103.8 ± 17.7min average blocking time of 51.2 ± 17.8min, average auxiliary Time is 31.2 ± 5.7min, pre congestive amount of 555.5 ± 46.3 m1, bypass the nose temperature average 28.5 ± 1.4 ° C. The result of the comparison of conventional hemodynamic parameters: heart rate (HR) before and after surgery the difference was statistically significant (P lt; 0.05); perioperative mean arterial pressure (MAP), central venous pressure (CVP) was not statistically significant (P gt; 0.05). The conventional color ultrasound indicators compare the results show: before and after surgery, left ventricular ejection fraction (LVEF), fractional shortening (LVFS), left ventricular end-diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) was not statistically significant (P gt; 0.05). Compare the results of the blood gas and biochemical indicators: intraoperative the transit flow with surgery than before, PH value differences without statistical significance (P gt; 0.05); of PaO2, BE, Hb, K difference was statistically significant (P lt; 0.05); surgery after 2h with surgery than before: PH value of K, the BE difference was not statistically significance (P gt; 0.05), PaO2, Hb difference was statistically significant (P lt; 0.05). The heart valves fluid dynamics indicators compare results: after prosthetic valve core sites of the different configurations of the turbulent shear stress (TSS) showed no significant difference (P gt; 0.05); the boundary locus TSS difference was statistically significance (P lt; 0.05). Conclusion: This study established the pig the MVR animal model can simulate real objective hemodynamic status of the human body MVR, the scientific method, feasibility. Comparative analysis of artificial heart valves retain full prosthetic structure downstream TSS Show: the largest single leaf mechanical valve, followed by Futaba mechanical valve bioprostheses minimum; Tip: three different configurations prosthetic valve hemodynamic School performance is better than poor single leaf mechanical valve bioprosthesis bileaflet mechanical valve in between. Consider from the principle of minimum stress of the prosthetic valve, mechanical valve hemodynamic performance is necessary to further improve.

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CLC: > Medicine, health > Medical research methods > Experimental medicine, medical experiments > Medical Laboratory Animal Science
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