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The Effection of Pulmonary Fibrosis on Erectile Function in Rats

Author: YuJunJie
Tutor: JiangZuo
School: Luzhou Medical College
Course: Surgery
Keywords: Pulmonary fibrosis Erectile dysfunction eNOS
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 13
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Abstract


Objective: To study pulmonary fibrosis erectile function in rats and its mechanism. Method: 40 12-week-old male SD rats were randomly divided into four groups: normal control 4 weeks (A group) and 6 weeks (B group) and pulmonary fibrosis in rats 4 weeks (C group) and 6 weeks (D 10) The determination of serum testosterone, arterial blood gas analysis, intracavernous pressure / mean arterial pressure (ICP / MAP), take the penis specimens NOS activity and cGMP content was measured, real-time fluorescent PCR detection eNOS.iNOS and the nNOS mRNA expression in the corpus cavernosum, Western blot analysis of the expression of eNOS corpora cavernosa. Results: C group ICP / MAP * 100,3 v, 5v (16.37 ± 2.19,27.19 ± 3.18) was significantly higher than in group A (30.78 ± 2.66,50.09 ± 6.97) lower (P lt; 0.05), Group D ICP / MAP * 100 , 3v, 5v (10.17 ± 1.31,17.40 ± 1.74) than in group B (31.45 ± 3.07,51.23 ± 7.23) was significantly lower (P lt; 0.05), Group D ICP / MAP * 100 value compared with the C group significantly reduced (P lt ; 0.05) in group C PO2 (75.50 ± 13.87) mmHg compared to the A group (103.80 ± 6.88) mmHg significantly with lower (P lt; 0.05), Group D PO2 (83.60 ± 5.50) mmHg compared with the B group (102.70 ± 5.77) mmHg significantly with lower (P lt; 0.05) the C serum testosterone levels (391.08 ± 264.65) ng / dl compared with group A (175.88 ± 52.97) ng/d1 significantly higher (P lt; 0.05) D serum testosterone levels (745.43 ± 408.84) ng / dl than in group B (177.79 ± 52.34) ng / dl was significantly higher (P lt; 0.05), while group D serum testosterone levels significantly higher than in group C (P lt; 0.05), C NOS activity and cGMP content (1.502 ± 0.140U/mgprot, 35.694 ± 3.638pmol/mg) than group A (2.656 ± 0.389U/mgprot, 51.103 ± 7.220 pmol / mg) was significantly lower (P lt; 0.05), D NOS activity and cGMP content (1.396 ± 0.199 U / mgprot, 34.554 ± 4.304 pmol / mg) than in group B (2.745 ± 0.356U/mgprot, 52.152 ± 6.855 pmol / mg) was significantly lower (P lt; 0.05), group C and group D NOS activity and cGMP content with difference (P gt; 0.05) in group C eNOS protein expression quantity (0.79 ± 0.01) compared to the A group (0.87 ± 0.01) significantly significantly reduce (P lt; 0.01), Group D eNOS protein expression quantity (0.71 ± 0.02) than in group B (0.88 ± 0.01) significantly with lower (P lt; 0.05), Group D than in group C eNOS protein expression amount significantly lower (P lt; 0.05), in group C of eNOS mRNA in the expression of the amount of (4.46 ± 0.92) compared with Group A (2.61 ± 0.68) significantly with increased (P lt; 0.05), Group D eNOS mRNA in (2.79 ± 0.60) expression of the amount and the B group (2.69 ± 0.65) without significantly with difference (P gt; 0.05), in group C than Group D eNOS mRNA expression was significantly elevated (P lt; 0.05), nNOS and iNOS mRNA expression in group A, B, C, D group had no significant difference (P gt; 0.05). Conclusion: Pulmonary fibrosis eNOS protein expression by inhibiting the corpora cavernosa, reduce total NOS activity and cGMP content mechanism to suppress erectile function.

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