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Background: Due to the inherent obstacles liver function in patients with cirrhosis of the liver, liver estrogen decrease in antidiuretic hormone and aldosterone hormone inactivated, resulting in water and sodium retention, easily lead to hyponatremia, combined with the clinical course of treatment given limit sodium salt diet, does not regulate the application of diuretics and large volume paracentesis and other measures, hyponatremia is more common in patients with cirrhosis (especially ascites). At home and abroad in recent years, studies have shown that the occurrence of hyponatremia with the complications of cirrhosis has a close relationship and affect the prognosis of patients with cirrhosis. Therefore, the diagnosis and prevention of hyponatremia in patients with cirrhosis, has begun to attract the attention of the majority of clinicians. Objective: To study cirrhosis with ascites relationship between the epidemiology of hyponatremia and hyponatremia in patients with cirrhosis complications (hepatic encephalopathy, hepatorenal syndrome, upper gastrointestinal bleeding, spontaneous bacterial peritonitis) of liver function Child-pugh score, MELD score in the short term (30 days) the relationship between mortality and to evaluate the clinical value of hyponatremia on the severity and prognosis of patients with liver cirrhosis, and improve clinical work The hyponatremia attention, and the reasonable sodium restriction of the patients with liver cirrhosis, diuretic therapy clinical guidance. Methods: A retrospective analysis from January 2010 to December 2010, the First Clinical Hospital of Jilin University, hepatobiliary and pancreatic internal medicine residents cirrhosis with ascites medical records. The excerpt patients within 72 hours of admission for the first time, serum bilirubin, serum creatinine, serum sodium, prothrombin time, international normalized ratio indicators, Child-Pugh classification and MELD score calculation admission extracted complications during hospitalization occurrence, telephone follow-up patients died (within 30 days after hospitalization). Patients were divided into normal serum sodium group and mild, moderate, and severe hyponatremia four groups, analysis of hyponatremia and complications of cirrhosis (hepatic encephalopathy, hepatorenal syndrome, digestion according to the degree of lower serum sodium tract bleeding, spontaneous bacterial peritonitis) the incidence, severity and hyponatremia with Child-Pugh classification, MELD score, short-term (30 days) mortality. Results: (1) cirrhosis with ascites patients with 756 cases, 235 cases of hyponatremia occur in approximately 31.08%, the mild hyponatremia 152 cases, accounting for 64.68% of the patients with hyponatremia, moderate hyponatremia in 53 cases, accounting for 22.55%; and severe hyponatremia 30 cases, accounting for 12.77%. (2) normal serum sodium group and mild, moderate, severe hyponatremia four groups in hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis and ascites severity differences were statistically significant (P lt; 0.05 each), with lower serum sodium, hepatic encephalopathy in cirrhotic patients with ascites, hepatorenal syndrome, spontaneous bacterial peritonitis incidence rate increased; and severity of hepatic encephalopathy, ascites increased incidence; in upper gastrointestinal bleeding The difference between the groups was not statistically significant (P gt; 0.05). (3) the different serum sodium liver function Child-Pugh classification, MELD score differences were statistically significant (P lt; 0.05), and lower serum sodium, Child-Pugh classification, MELD score gradually increased; (4) normal serum sodium group and mild, moderate, severe hyponatremia four groups in the short-term mortality (30 days), the difference was statistically significant (P lt; 0.05), with the sodium concentration is reduced, short-term mortality increased. Conclusions: (1) patients with liver cirrhosis and easy with hyponatremia, the study reached 31.08%. The difference was statistically significant (2) of hyponatremia and extent of hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, ascites severity, hyponatremia is the more serious, spontaneous bacterial peritonitis, hepatic encephalopathy , hepatorenal syndrome, the higher the incidence of massive ascites, hyponatremia hair and upper gastrointestinal bleeding incidence of no significant correlation. (3) the degree of hyponatremia and liver function Child-pugh classification, MELD score, that the lower sodium levels, liver function Child-pugh classification, the worse the MELD score. (4) hyponatremia and the degree of short-term mortality (30 days), patients with liver cirrhosis, the lower sodium concentration, the higher the short-term mortality.
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