|
Chronic heart failure is the most common form of heart failure, the incidence gradually increased in recent years, including coronary atherosclerosis, heart disease is the main cause of disease. The drug treatment of chronic heart failure in the recent ten years and has seen much progress. This paper reviewed the new progress of Chinese and Western medication for chronic heart failure caused by coronary atherosclerotic heart disease. Summary consists of three main parts. First, the new progress of modern medicine, drug treatment of heart failure with chronic coronary heart disease. At home and abroad with chronic heart failure guide treatment drugs - angiotensin-converting enzyme inhibitors / angiotensin II receptor antagonists, diuretics, aldosterone receptor antagonists, beta-blockers, inotropic The mechanism of action of drugs, evidence based medicine and indications detail, recent scholars β-blockers and aldosterone receptor antagonist (eplerenone) in the treatment of chronic heart failure some new ideas; energy metabolism of drugs can improve energy metabolism and nutritional status of myocardial cells in ischemia and hypoxia so that it can also be applied to the treatment of heart failure; recent years because traditional medicines or side effects of light or heavy some can be confirmed by clinical trials for new drugs against heart failure, have a good prospect, such as the renin inhibitor Ⅰ inhibitors vasopressin receptor antagonist, natriuretic peptide endothelin receptor antagonist agent, a calcium sensitizer, istaroxime; being studied in a pharmaceutical, the existing the basis yet fully supports for the treatment of heart failure, such as neutral endopeptidase inhibitors, adenosine receptor antagonists, growth hormone, etc. , there are a number of drugs found in the phase of theoretical research or animal studies may have anti-heart failure, such as myosin activator, inflammatory cytokine receptor antagonists, hormone replacement treatment, these drugs for the treatment of heart failure has opened up new ideas and approaches; There are as statin lipid-lowering drugs, etc. Although there is no heart failure indications but studies have shown that drugs may benefit with the combined effects of other drugs, these drugs, the mechanism of anti-heart failure, application prospects and existing problems one by one exposition concludes with a brief discussion of the treatment of diastolic heart failure, as well as its point with systolic heart failure medication. The second part is the understanding of Chinese medicine for chronic heart failure. In medicine for chronic heart failure gradually deepening understanding of the great advantages of traditional Chinese medicine in the treatment of heart failure. Discusses many of the etiology and pathogenesis of heart failure, basically the same point, that heart failure is a disease in this vacuity, yang qi deficiency-oriented, and water to drink blood stasis, stop as standard. Heart failure combination of more than eight principal viscera dialectical parting, but dialectical type the different reported is not the same, this article by reference to the summary of the literature and clinical experience to be classified as six kinds. Modern pharmacological studies of single herbs and animal experiments found that traditional Chinese medicine has a role to improve the patient's hemodynamic provides a theoretical basis for traditional Chinese medicine treatment of heart failure, and then discusses the different formulations of traditional Chinese medicine decoction, injections, capsules, etc. with heart bad treatment-related clinical reports and research. The last part is the outlook of Chinese and Western medicine in the treatment of coronary heart disease heart failure. Respectively, summed up the advantages of Western and Chinese medicine treatment of heart failure, inadequacies and should be further explored.
|