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Objective: To investigate Naoxintong Capsules ( Naoxintong Capsule , NXT ) joint dual antiplatelet therapy ( dual antiplatelet therapy , DA ) treatment effects on rat autologous coronary micro- embolization ( coronary microembolization CME ) . Methods: while clamping the ascending aorta from the apical micro- injected into the homologous rat thrombosis (rat autologous blood clots by the 38μm mesh filter made ??) CME model . 95 uneven rats were randomly divided into six groups , the control group ( n = 10 ) , sham operation group ( n = 10 ) , the CME group ( n = 15 ) , the NXT group ( n = 15 ) , the DA group ( n = 30 ) , the NXT the United DA group (NDA group , n = 15 ) . Preoperative pre - administered 3 days , patients continue medication 7 days , animals were sacrificed after blood collection of specimens . A total of 69 rats for complete data . Hematoxylin - eosin staining percentage of the number of CME ( CME ) , the tails assay hemorrhage ( bleeding time , BT ) , the slide method detection clotting time ( clotting time , CT ) , nephelometry detection of adenosine diphosphate induced platelet aggregation (platelet aggregation rate, PAR), automatic blood analyzer platelet count , enzyme-linked immunosorbent assay detection of P-selectin , interleukin- 6 ( interleukin - 6, IL - 6 ) , IL -10 endothelin- 1 (endothelin-1, ET-1) and endothelial nitric oxide synthase (endothelial nitric oxide synthase, eNOS). Results: 1 . Compared with the control group and the sham-operated group , the the CME group of CME , PAR , P select prime , IL-6 and ET-1 was significantly higher ( P lt ; 0.01 ) , BT , CT , IL - 10 and eNOS was significantly lower ( P lt ; 0.01 ) ; 2 compared with the CME group , the drug treatment group BT , CT , IL - 10 and eNOS was significantly higher ( P lt ; 0.05 or P LT ; 0.01 ) , CME , PAR P - selectin , IL-6 and ET-1 was significantly lower ( P lt ; 0.05 or P LT ; 0.01 ) ; longest in which the DA group BT and CT , PAR and the lowest P-selectin , and IL-10 of the NDA group and eNOS highest , CME % , IL - 6 and ET ??-1 minimum ; 3 . platelet count was no significant difference ( P gt ; 0.05 ) in each group . Conclusions: 1. Naoxintong capsule combined with dual antiplatelet therapy may regulate the pro-inflammatory cytokines and anti-inflammatory cytokines and ET-1 and eNOS balance by inhibiting platelet aggregation, a significant reduction in rats CME CME % . 2 Naoxintong capsule combined with double antiplatelet therapy can also reduce the risk of dual antiplatelet treatment of bleeding .
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