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Effects of NXK Ⅱ HKFY on the Content of Troponin T in Rats of Myocardial Ischemia Injury

Author: LiuTong
Tutor: DongYuXiang
School: Jilin University
Course: Traditional Chinese Medicine
Keywords: NXKⅡHKFY myocardial ischemia(MI) PIT CTn-T
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
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Abstract


Objective:This experiment through the observation of the damaged cardiac cells NXKⅡHKFY that a traditional Chinese medicine preparation composed for the method for phlegm and blood stasis mutual resistance and deficiency of Qi Troponin T (CTn - T) content influence, Discuss the clinical effect mechanism, To provide the basis for clinical dialectical medication.Methods:This study for animal model test,60 Rats were randomly divided into 6 groups,that is the normal, the group of model of MI, the control group of DXSYSLZ, low-dose group of NXKⅡHKFY, midst-dose group of NXKⅡHKFY and high dose group of NXKⅡKFY. After 20 days’treatment of the medicine we inject PIT to the rats and make the model of MI, then monitoring them with ECG. After making sure the model is right, we get the blood and myocardial tissue. Then testing the changing of the content of CTn-T in the blood-serum, and the myocardial tissue pathology change. Result:NXKⅡHKFY compared with negative group can effectively improve myocardial ischemia abnormal ECG,Also can lessen the content of CTn - T, Reduce myocardial tissue damage.Conclusion:After NXKⅡHKFY prophylaxis, For PIT cause J point up (or down) and T wave up are obviously Antagonist role, It can lessen the content of CTn - T and reduce myocardial tissue damage. Its mechanisms can be and that the voltage dependence and the receptor ca2+ channels regulating capability is blocked, make the ca2+ of the extracellular Flow inside and the ca2+ of the cell outside, It can relaxation vascular smooth muscle, Reduce coronary artery vasospasm, Dilating coronary arteries, Increased coronary artery blood flow, Improve the myocardial blood oxygen supply relevant.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
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