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Coronary heart disease as a serious threat to human health killer, how to reduce the incidence and mortality of coronary heart disease has always been the focus of modern medical research field and one of the hot spots. Syndromes is a comprehensive response to a certain stage in the disease process (de facto) made by the body's internal and external pathogenic factors. Syndromes in the occurrence of coronary heart disease, the development and transfer process, is always in the process of dynamic change. TCM syndromes of coronary heart disease evolution research helps to grasp the evolution and development of the pathogenesis of coronary heart disease outcomes, and improve the standard of TCM clinical syndrome, early identification and intervention in high-risk patients, to further reduce the incidence of cardiovascular events has important significance. The two parts of this thesis, including literature review and clinical observations. Literature Review: Review the status of recent years, traditional Chinese medicine syndrome evolution and coronary heart disease, congestive heart failure, viral myocarditis and other cardiovascular disease TCM syndrome evolution. That the current study used a cross-sectional survey, longitudinal study, retrospective study, clinical design, by comparing disease at different time points, different stages or in patients with different stages of TCM syndromes constituent ratio or a certificate designate a percentage, as well as syndromes transition probability TCM climate evolution, made some progress. played a positive role for the to improve clinical Diagnosis and Treatment effect. Together, is not yet stable period of coronary heart disease in patients with thrombotic cardiovascular events in the the card Hou evolution, and, in view of the traditional Chinese medicine syndrome is a high-dimensional, dynamic, nonlinear complex systems, future research should longitudinally The research-based, dynamic observation time points, and make full use of multivariate statistical analysis and data mining multidisciplinary approach and close analysis combined with traditional Chinese medicine theory and clinical practice. Clinical Observation: Objective: Stable Coronary Heart Disease patients enrolled within six months to a year whether the occurrence of thrombotic cardiovascular events as the standard, divided into event group and the non-event group, for a different point in time clinical information in real-time, dynamic collection after, into the group, six months, one year syndrome elements distribution characteristics were observed to the study of coronary heart disease patients with stable occurrence of thrombotic cardiovascular events permit Hou evolution. Methods: The study the four diagnostic information based on the acquisition of coronary heart disease patients with stable, refining a Hanning Qi stagnation, phlegm, phlegm, blood stasis, qi deficiency, yang, yin card toxic syndrome of 9 syndrome factor analysis of all coronary heart disease patients with stable event group and the non-event group distribution syndrome elements selected after three time points (into the group, six months, one year), the use of the frequency distribution method to observe the event group distribution characteristic of syndrome elements of the non-event group patients, and data mining methods using multifactor dimensionality reduction (MDR) and complex network to explore coronary heart disease patients with stable card Hou change its thrombotic cardiovascular events evidence Hou evolution . Results: A total of 1333 patients were observed, the events of the 37 cases, the non-event 1296 cases, phlegm, blood stasis, qi deficiency, toxic syndrome patients with stable coronary heart disease characteristics Cheng Hou, along with the extension of the follow-up time, coronary heart disease in patients with a single card Hou constituent ratio decreased to varying degrees of trend. Compared with non-event, event group into the group Qi deficiency, toxic syndrome ratio higher proportion of phlegm lower (P lt; 0.05 or P lt; 0.01); event group for six months when Qi deficiency, toxic syndrome, qi stagnation permit a higher proportion (P lt; 0.05 or P lt; 0.01). The MDR results show that the the qi deficiency enrolled toxic syndrome and six months follow-up, blood stasis, Qi deficiency and blood stasis in the six months follow-up interaction with cardiovascular events positively correlated to reflect the occurrence of cardiovascular events in patients due to The poison caused stasis, toxin gas consumption Syndrome evolution. Complex network analysis results show that the network diagram node = 8:00, the occurrence of cardiovascular events in patients with toxic syndrome to enrolled six months follow-up qi deficiency, qi deficiency syndrome in the six months follow-up blood stasis, enrolled as a major node, reflecting toxic syndrome, qi deficiency, blood stasis into each other, consistent with the MDR analysis. Conclusion: blood stasis, phlegm, qi deficiency, toxic syndrome of coronary heart disease patients with stable card Hou toxic syndrome, qi deficiency syndrome characteristics for the occurrence of cardiovascular events in patients. As the follow-up time, coronary heart disease patients with stable TCM climate continue to evolve, due to drug induced stasis, stagnancy each node; toxin evil the gas consumption QDBS possible occurrence of cardiovascular events in patients with critical disease and its The Designate evolution, worthy of further study.
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