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In this study, by animal experiments and clinical research, to explore the righting Peiyuan particles improve the effect of qi and blood loss patients with cancer syndromes, and immune function in cancer patients. Part I: Clinical research methods: the 90 enrolled patients were randomly divided into a treatment group and a control group, treatment group, 60 cases in the control group of 30 patients. Treatment group righting Peiyuan particle particle standard treatment; the control group Zhenqifuzheng particulate standard treatment. Treatment periods: 3 weeks. Were compared before and after treatment, the main symptom improvement, weight changes, Cartesian points, changes in immune function, etc.. Results: The two groups on the improvement of TCM syndrome of qi and blood loss compared with the treatment group, the effective rate is 8.33%, with a total effective rate of 91.67%. And the control group, the effective rate is 6.67%, with a total effective rate of 80%. Comparison of two groups, the difference was not significant sexual meaning, but the treatment group than the control group. The righting Peiyuan particles improve shortness of breath, fatigue Shenpi, dizziness, palpitations and side to improve the efficacy of immunity aspects, and compared to the control group, the difference was not statistically significant. Conclusion: The righting PEIYUAN particles can be effective in treating cancer patients after radiotherapy and chemotherapy, shortness of breath, Shenpi fatigue, dizziness, heart palpitations, sweating blood deficiency symptoms and found no obvious side effects reaction worthy of clinical application. Part 2: Test methods: 90 healthy BALB / C male mice according to the random principle, divided into five groups, n = 16 packet followed by a blank control group, of righting PEIYUAN particles small dose group, righting element particles in the dose group, the righting PEIYUAN granular high-dose group, Zhenqifuzheng particle group. 90 healthy BALB / C female mice also grouped according to the above method. Blank control group were given double distilled water, the righting of small particles, the drug concentration in the high-dose group were 0.09333g/ml, 0.18667g/ml, 0.37333g/ml, the particles group Zhenqifuzheng drug concentration is 0.16667g/ml mice in each group were ig administration same volume (0.15ml/1Og and body weight), once daily dosing, weighing the body weight of mice to adjust the dose administered continuously for 30 days a week. Each group were randomly selected mice 8, 30min after the last administration, the base of the tail load of 5% of their body weight heavy objects on swimming in the swimming tank water depth of 50cm, the water temperature at 37 ° C. Record mice swimming time. Of each randomly selected mice 8, 30min after the last administration, not weight placed swimming tank swimming, water depth of 5 Ocm, water temperature 37 ° C. After 90 min, the mice were killed, and detection of the mice in each group glycogen content, blood urea nitrogen content of blood lactic acid content and immune function. Results: 1. The righting PEIYUAN particles of medium and small doses can significantly prolong the weight swimming time and significantly improve fatigue mice glycogen reserves, the most obvious effect of middle dose group and female group was significantly better than the male. The righting Peiyuan particles had no significant effect on fatigue in mouse blood lactate content. , In dose can significantly reduce fatigue in mice blood urea nitrogen content, the most obvious medium dose group, and no significant difference between male and female; in dose can significantly improve fatigue in mouse blood CD3, CD4 cell levels, and female no significant difference between and male. Large, medium and dose can significantly improve fatigue in mouse blood CD8 cell levels, the high-dose group, females was significantly higher than the male; righting Peiyuan particles on fatigue in mouse blood NK cell levels had no significant effect. Conclusion: the righting PEIYUAN particles dose can effectively improve endurance antifatigued obvious effect on the fatigue mice glycogen BUN content, can significantly improve the fatigue mouse blood CD3, CD4, CD8 cell count.
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