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Preparation of Poly "3-(Trimethoxysilyl) Propyl Methacrylate-Co-2-(Methacryloyloxy) Ethyl 2-(Trimethylammonio) Ethyl Phosphate" Via Atrp and Studies of It’s Blood Anticoagulation Activity

Author: DingWenQuan
Tutor: ShenJian；ChenQiang
School: Nanjing University
Course: Chemical Engineering
Keywords: Block copolymers Living Radical Polymerization 2 - methacryloyl acyloxyethyl phosphorus phosphatidyl choline Antithrombogenicity Surface Modification
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 95
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Abstract


Biological material has been widely used in the biomedical field , such as artificial organs, as well as a variety of therapeutic and diagnostic medical material (Medical Devices) . And biocompatibility, in particular, blood compatibility is the most important performance of the biomedical materials . Improve the blood compatibility of the materials has been one of the main content of biological materials research and development (R \u0026 D) . The fight against the a clotting material of research for more than half a century , made ??great progress in three categories: polyoxyethylene structure class , widely recognized in the international anti-clotting better material , poly the phosphorylcholine class and heparin surface material . But these anticoagulant material Cardiovascular implants and cardiovascular medicine was still can not meet the need for blood compatibility and therefore study of new anticoagulant material has a great significance . An important way for the development of biological materials in appropriate physical and mechanical properties of the material to build a specific molecular structure , in order to achieve the unity of the physical and mechanical properties of biological materials and biocompatibility . In accordance with the \1HNMR, FTIR testing showed that successfully synthesized a block copolymer, and for a preliminary study on the polymerization kinetics by GPC , also found that the dissolution properties of the amphiphilic block copolymer . The use of this block copolymer cellulose membrane and a silicon rubber membrane surface modification , surface static water contact angle , platelet adhesion and other methods of the wetting properties of the grafted membranes and blood compatibility were evaluated . The experimental results show that the two types of membrane surface hydrophilic been strengthened after modification , at the same time greatly improve the anti-platelet adsorption , preliminary indication of increased anticoagulant properties .

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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