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Biomedical Materials (Biomedical Materials) is a class of special features, can be applied to disease prevention, diagnosis, treatment and rehabilitation to restore, enhance tissue function, or direct replacement of biological tissues, organs, a class of materials. Polyurethane (Polyurethane, PU) is a common biomedical materials, both good biocompatibility and mechanical properties. Chitosan (Chitosan, CS) is a natural amino polysaccharide, has abundant reserves, good biocompatibility, biodegradability, and biological activity of a series of excellent performance. Gold nanoparticles (Au Nanoparticles, AuNPs) for biomedical favored because of its good biocompatibility. Layers of self-assembled multilayers (Layer-by-layer, LBL) has a very wide range of applications because of its special multi-layer structure, in the direction of biomedical materials. In this paper, we use different amounts of gold particles modified polyurethane / chitosan biological affinity and materials, as raw material with electrostatic polyurethane and chitosan with the spin coating manner to the preparation of self-assembled multilayer film materials. Around the above content to carry out the work of the following two parts: (1) with different concentrations of AuNPs the PU / CS biological affinity material is modified to cover the time (Recalcification Time, RT), coagulation three, including the thrombin time (thrombin time, TT), prothrombin time (prothrombin time, PT) and activated partial activating enzyme (activated partial thromboplastin time, APTT) and cell culture tests, the modified material biocompatibility, cytotoxicity and anti- The coagulation performance of a series of studies. Change the AuNPs incorporation of biological performance enhancing effect. Finally consolidated the indicators will be prepared by the incorporation of gold nanoparticles in 100μg / g PU / CS substrate, laying the groundwork for a follow-up study. (2) In order to improve the anti-clotting properties of materials, we introduce LBL structures, and the spin-coating process of the multilayer film is carried out a preliminary attempt. Characterization of the thickness of the multilayer film, the hydrophilic and the surface smoothness of the SEM, AFM, the contact angle with water and the drug package containing sustained release. We observed a linear growth of the electrostatic self-assembly film thickness of the multilayer film, as the film thickness increases the surface becomes smooth, regular changes of the different surface water contact angle, and the multilayer film in the drug package containing a sustained-release release curve chemotactic nearly linear series of nature. Collectively, these results outstanding performance in a range of biological properties of AuNPs modified biological materials, its implantation in the human body, to become a biomedical material with more confidence. Multilayers material modification of the surface of the base material, the material surface properties intuitively obvious changes, we have reason to believe there is some value in improving the anticoagulant properties of biological materials.
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