Dissertation > Excellent graduate degree dissertation topics show

The Study of rhBMP2 Composite Materials on Bone Regeneration

Author: ChenYang
Tutor: WangJu
School: Jinan University
Course: Genetics
Keywords: BMP2 chitosan control-release nanofibers
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 34
Quote: 0
Read: Download Dissertation

Abstract


It is a problem in clinic to repair of bone defects caused by varieties factors. Traditional therapy such as autogenous bone graft exist certain flawed. With the development of tissue engineering and molecular bionics, many researches study on the field of biological material. But poor biocompatibility and bone repair capacity restrict the applicant of bone repair material. BMP2 is widely used in clinic as a key growth factor which can not be control released and is easily degradation by enzyme.To solve the problems above, in this study, the design of bioactivity is based on the potential ability to bind and slowly release CS/HA-binding growth factors. To engineer a nano-fibrous scaffold with three-dimensional network structure, in this work, chitosan nano-fibers mimicking the natural ECM fibers were prepared by phase separation.The surface morphology, porosity and whether the BMP2 is binding to the CS/HA of scaffold were characterized by scanning electron microscopy (SEM) and FTIR test respectively. The results showed that CS nano-fibers with BMP2 has a diameter of 50-500nm distributed in each pore and formed three-dimensional network structure. Drug release research indicated the nanofibers were excellent carriers of BMP2 Futhermore the results of C2C12 and material co-culture experiment told us that nanofibers had a good cellular compatibility, while the animal experiments show the biological activity of BMP2 which can promote new bone formation.

Related Dissertations

  1. Studies on Chitosan and Its Derivatives Adsorption for Paralytic Shellfish Poisoning in Ostrea Rivularis Could,TS254.4
  2. Thermal Stability of Complexes of Chitosan Quaternary Ammonium Salt and Metal Ion,O634
  3. Polyethylenimine Conjugated Stearic Acid-g-chitosan Oligosaccharide Micelles for Antitumor Gene Therapy,R450
  4. Preparation and Characterization of the OCS/PLLA Composite Film for Biomedical Materials,R318.08
  5. Study on the Accumulation and Remove of Cadmium and Lead in Oysters,X174
  6. Study on the Synthesis and Adsorption Behaviour of Chitosan Derivative,TS254.9
  7. Improvement of Preparation Technology for Chitin and Chitosan from By-product of Litopenaeus Vannamei,TS254.9
  8. Biological Control of Meloidogyne Spp. in Cucumber (Cucumis Sativus L.) and Development of the Ecological and Environment-friendly Fertilizer with Pesticides,S436.421
  9. Preparation and Properties of Chitosan-based Thermosensitive Composite Hydrogel,R943
  10. Acid solution on the structure and properties of chitosan / hydroxyapatite composite,R318.08
  11. Preparation and Characterization of Polymer Micro/Nano Fibers by Laser Melt Electrospinning,TQ340.64
  12. Study on Chitosan-Based Composiate Nano-Coating Dope and Its Effect of Fresh-Keeping for Coated Egg,TS253.2
  13. Studies on the Dissolution of Chitosan in Ionic Liquids,O636.1
  14. Application Adipose-devired Stem Cells and Silk Fibroin and Chitosan Scaffold Materials Building Common Cells-stents Complex Experiments,R329
  15. Bovine serum albumin and protamine from NOCC / alginate hydrogels release : the isoelectric point of two different biological molecules controlled trial,R943
  16. PVA / Polystyrene Composite Nanofibers Preparation and Characterization,TQ340.1
  17. Studies on the Tumor Targeting of RGD Peptide Modified Stearic Acid-g-Chitosan Oligosaccharide Polymeric Micelles,R943
  18. The Marrlid Reaction of Chitosan Oligsccarids and the Antioxidant Activity of It’s Derivatives,R285
  19. Application of Glycol Chitosan-based Hydrogels in Tissue Engineering and Drug Delivery,R943
  20. Preraration and Properties of Carbon Nanofibers and Their Composites,TB383.1
  21. Preparation of Nanofibers Modified Electrode and Its Electrocatalytic Properties,O646

CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
© 2012 www.DissertationTopic.Net  Mobile