Dissertation > Excellent graduate degree dissertation topics show

The Effect of Selective Androgen Receptor Modulator (Sarm) on Bone in Osteopenic Male Rats

Author: YangChaoBo
Tutor: LiuWenGe
School: Fujian Medical
Course: Surgery
Keywords: osteoporosis Selective Androgen Receptor Modulator bone mineral density Biomechanical property
CLC: R965
Type: Master's thesis
Year: 2011
Downloads: 16
Quote: 0
Read: Download Dissertation

Abstract


Objective This study was designed to evaluate the skeletal effects of s-3-(4-acetyla mino-phenoxy)-2-hydroxy-2-methy1-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide in an osteopenic model.Methods Osteoporosis rats model was developed successfully by tcastrate, then treatment with subcutaneous injection of Dihydrotestosterone (DHT)and Sarm was applied in the next 12 weeks.Measurement of bone mineral density(BMD) and biomechanical properties of femur and lumbar vertebra,prostate weight and biochemical assays of serum were recorded after the termination of therapy.Result 1.The BMD of orx group in whole-body,femur and lumbar vertebrae is obviously lower than sham group(P<0.001),treatment using Sarm of middle and high is obviously higher than orx group(P<0.01),The BMD of treatment using Sarm of low increased BMD but not obviously.The BMD of treatment using Sarm of middle ,high and DHT group is obviously higher than sham group(P<0.01),The group of treatment using Sarm of middle ,high and DHT was showed no significant difference.2. The Biomechanical properties of orx group in femur and lumbar vertebrae is obviously lower than sham group(P<0.001), treatment using Sarm of middle and high is obviously higher than orx group(P<0.01),The group of treatment using Sarm of low increased Biomechanical properties but not obviously.The Biomechanical properties of treatment using Sarm of middle ,high and DHT group is obviously higher than sham group(P<0.01),The group of treatment using Sarm of middle ,high and DHT was showed no significant difference.3.the orx group serum Ca obviously decrease,serum P obviously increase ,serum BALP obviously increase (P<0.001);after 12 weeks treatment, serum Ca and serum P of every group was showed no significant change. The serum BALP of treatment using Sarm of middle ,high and DHT group is obviously;lower than orx group(P<0.001),The serum BALP of treatment using Sarm of middle ,high and DHT group is obviously lower than orx group(P<0.001),The group of treatment using Sarm of middle ,high and DHT was showed no significant difference.4.The prostate wet wight and prostate exponent of sham group is obviously higher than orx group(P<0.001), The group of treatment using Sarm of low,middle and sham was showed no significant difference. The group of treatment using Sarm of high prostate slightly hyperplasia.it was showed significant difference and Biomechanical properties,Meanwhile,it decreased the levels of serum Bone Alkaline phosphatase,but not to cause prostate significant hyperplasia(P<0.05);The groups of treatment using Sarm was showed no significant difference.,not to cause prostate significant hyperplasia.Conclusion The ability of Sarm to promote bone mineral density and Biomechanical properties of osteopenic male rats.Position these drugs as promising new alternatives for the treatment of osteoporosis.

Related Dissertations

  1. Chronic obstructive pulmonary disease osteoporosis and TCM kidney deficiency syndrome research,R259
  2. Clinical Significance of Bone Metabolic Markers in the Diagnosis and Treatment to Old Patients with Osteoporosis Fracture,R580
  3. Clinical Study on Salmon Calcitonin Treatment on the Osteoporosis among Postmenopausal Women,R580
  4. Effect of Zoledronic Acid on Bone Mass and Biomechanics in Orchidectomized Rats,R580
  5. Discuss of Related Knowledge and Risk Factors About Osteoporosis in High-risk Groups,R580
  6. A Study to Observe the Alternations of Bone Mass in Women with Systemic Lupus Erythematosus after Long-term Treatment with Glucocorticoids,R593.241
  7. Serum 25-hydroxy Vitamin D Level in Diabetic Patients and Its Effect on Blood Glucose and Bone Mass,R587.1
  8. Effects of Chinese Herbs Semen Astragali Complanati, Rhizoma Cibotii, Herba Cistanches, and Semen Allii Tuberosi on Osteoporosis in Ovariectomized Rats,R285
  9. Study on Extraction of Deer Collagen and Therapeutic Effects of Collagen on Osteoporosis,R285
  10. Clinical Research of Primary Osteoporosis Treated by Jinguishenqiwan-Calglucon,R580
  11. The Effects of Transplantation of Allograft Adipose-derived Stem Cells in Glucocorticoid-induced Osteoporosis Rats,R580
  12. Study of Correlation between Serum Adiponectin Level and Arteriosteogenesis in Patients with Osteoporosis,R580
  13. Study on Association of Diet with Bone Mineral Density Among Middle and Old Aged Women in Hefei City,R151.4
  14. Primary osteoporosis risk factors and TCM syndromes and fracture analysis,R259
  15. Bones Capsule the Treatment of Primary Osteoporosis Clinical Research,R259
  16. The Relationship between Plasma AOPP and Osteoporosis in Postmenopausal Women,R580
  17. Metformin Stimulates Osteoprotegerin and Reduces RANKL Expression in Osteoblasts and Ovariectomized Rats,R580
  18. Experimental Study of Constructing Osteoporosis Models by Steroid Inducing Ovariectomized Goat,R580
  19. Association between Bone Mineral Density and Coronary Artery Calcification in Aged People,R580
  20. Investigation of Pull-out Strength on a Part Concentrated Screw Designation in Human Spine and Finite Element Analysis Model.,R687.3
  21. Evaluation on the Risk Factors of Re-fracture in Elderly Osteoporosis Patients,R683

CLC: > Medicine, health > Pharmacy > Pharmacology > Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile