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Dermatology background Psoriasis is a common disease, frequently-occurring disease, men and women may be the disease, its exact pathogenesis has not been fully elucidated, a variety of factors involving genetic, immune, inflammatory, neurotransmitters, cell proliferation and apoptosis. At present, most scholars believe that psoriasis is an immune-induced excessive regenerative proliferative skin disease. Superantigen stimulation of T lymphocytes, T cells and the interaction KC, abnormal cytokine of STAT3 pathway, abnormal immune cell membrane molecules, Toll receptor, and nerve immunity plays an important role in the pathogenesis of psoriasis. Objective To investigate Serum levels of MCP-1, MIP-1α, SCD40L, TNF-α, EGF, IL-8, IL-10, IL-17 and VEGF levels TCM type, severity of illness, disease the relationship between the periods. Method using enzyme-linked immunosorbent assay (ELISA) of 62 patients with psoriasis and 20 healthy human serum cytokines (MCP-1, MIP-1α, sCD40L, TNF-α, EGF, IL-8, IL-10 , VEGF) were measured, and analyzed its relationship with the TCM syndrome. Showed high expression results 1.EGF, compared with the healthy control group, no statistical significance (P gt; 0.05); TCM syndrome type comparison was not statistically significant (P gt; 0.05); disease staging, PASI score unrelated (P gt; 0.05); (P lt; 0.01) associated with the course. 2.IL-8 was highly expressed in blood stasis group most representative significance, blood stasis group and the healthy control group, dryness syndrome group compared with the healthy control group, a significant difference (P lt; 0.01); with the disease activities, PASI score, duration of unrelated (P gt; 0.05). With age 3.IP-10 was highly expressed in blood stasis group most representative significance, blood stasis group and the healthy control group, dryness syndrome group compared with the healthy control group, a significant difference (P lt; 0.01); gender-related (P lt; 0.05); disease staging, PASI score, duration of unrelated (P gt; 0.05). 4. MCP-1 was highly expressed, compared with the healthy control group, no significant differences (P gt; 0.05); the BSS group compared with the healthy control group, a statistically significant (P lt; 0.05); gender-related (P lt; 0.05); disease staging, PAS I score independent of disease duration (P gt; 0.05). 5. MIP-1α was highly expressed, compared with the healthy control group, a significant difference (P lt; 0.01); BSS group and the healthy control group, the the dryness syndrome group and the healthy control group, a significant difference (P lt with the stage of the disease, PASI score, duration of independent (P gt; 0.05); 0.01); 6. TNF-α was highly expressed compared with the healthy control group, a significant difference (P lt; 0.01); BSS group and the healthy control group, the the dryness syndrome group and the healthy control group, a significant difference (P lt with the stage of the disease, PASI score, duration of independent (P gt; 0.05); 0.01); 7. VEGF was highly expressed, compared with the healthy control group, no statistical significance (P gt; 0.05); Chinese Medicine of the comparison between the various syndromes, was not statistically significant (P gt; 0.05); course of the disease related (P lt; 0.05);, and disease staging PASI score unrelated (P gt; 0.05). 8.IL-17 showed low expression, compared with the healthy control group, no statistical significance (P gt; 0.05); TCM syndrome type comparison, no statistical significance (P gt; 0.05); subsided and stable stages involuting during the comparison was statistically significant (P lt; 0.01); the with PAS I score, duration of unrelated (gt; 0.05). 9. SCD40L most representative showed low expression, Xuezao syndrome group compared with the healthy control group was statistically significant (P lt; 0.05); disease staging, PAS I score independent of disease duration (P gt; 0.05) . The conclusion 1.EGF in the serum of patients with psoriasis, high expression, and disease progression. 2.IL-8 is highly expressed in the serum of patients with psoriasis, and its detection may be used for blood stasis syndrome, dryness syndromes TCM dialectical type psoriasis and other evidence psoriasis. 3.IP-10 high expression in the serum of patients with psoriasis, its detection may be used for blood stasis, dryness syndromes psoriasis and other syndromes of TCM dialectical type psoriasis, their expression levels with age, gender related. 4.MCP-1 is highly expressed in the serum of patients with psoriasis, and its detection may be used in traditional Chinese medicine dialectical type psoriasis of blood stasis syndrome and other syndromes of psoriasis, the expression level of gender-related. 5. MIP-1α in the serum of patients with psoriasis high expression of detection may be used for blood stasis, dryness syndromes psoriasis and other evidence psoriasis TCM dialectical type. 6. TNF-α in the serum of patients with psoriasis high expression of detection may be used for blood stasis, dryness syndromes psoriasis and other evidence psoriasis TCM dialectical type. 7. VEGF in the serum of patients with psoriasis high expression with disease progression. 8.IL-17 in the serum of patients with psoriasis low expression with disease activity. 9. SCD40L low expression in the serum of patients with psoriasis, its dryness syndromes psoriasis and other evidence of psoriasis may be used in traditional Chinese medicine dialectical type detection. 10. Cytokine expression abnormalities in the pathogenesis of psoriasis plays an important role, there are some positive role between abnormal cytokine.
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