Dissertation > Excellent graduate degree dissertation topics show

Study on 3D Protein Folding Problem Based on the Improved Hysteretic Optimization

Author: XiongRu
Tutor: XuWeiHua；LvYongZai
School: Zhejiang University
Course: Control Theory and Control Engineering
Keywords: Protein Folding Three - dimensional lattice model Hysteresis optimization algorithm Parameter definition
CLC: TP301.6
Type: Master's thesis
Year: 2012
Downloads: 20
Quote: 0
Read: Download Dissertation

Abstract


The protein folding problem is one of the core issue of Bio - IT research it to be resolved is how the amino acid sequence of the protein primary structure is folded into a three-dimensional structure of the problem . The study of protein folding mechanism of the entire process of complete biological information transfer , thus revealing the laws of life activities is important. In recent years , the intelligent computing plays an increasingly important role in modeling , prediction and optimization of the protein folding problem . This article describes a new type of physical optimization algorithms - the hysteresis optimization algorithm (HO), applied to three-dimensional protein structure prediction problem ; and on the basis of this work , in-depth study of the hysteresis characteristics of optimization algorithms and protein folding proposed effective improvements methods . First of all, the first time the hysteresis optimization algorithm is extended to solve three-dimensional protein folding problem . The hysteresis optimization algorithm inspired by physics AC demagnetization process attenuation by simulating alternating external magnetic field demagnetization process to solve the optimization problem . Zar a nd et al in 2002 for the solving of the spin glass model . Concluded through the analysis of simulation results : the hysteresis optimization algorithm is composed by a variety of \The objective function ( lowest energy state ) to establish links between the three , the \Furthermore, based on previous research , successful algorithm improvements, simulation results in the application of the results of the comparison with other intelligent algorithms , not only to obtain better results , faster computing speed ; especially for a length of 64 sequence to find a lowest energy value -57 conformation , only to find other algorithm for solving the conformation of the lowest energy -56 . Finally, the application of the hysteresis optimization algorithm for solving the three-dimensional protein folding problem is a summary and outlook of future research work .

Related Dissertations

  1. Hysteresis -based optimization of vehicle routing problem,O224
  2. A Study on Prediction of Protein Fold Based on Machine Learning,Q51-3
  3. The genetic annealing method to predict protein structure,Q51
  4. A Study on Applying Particle Swarm Optimization Algorithm,TP301.6
  5. Studies on Displacement Adsorption Enthalpies and Conformational Change of Denatured Bovine Serum Albumin on Hydrophobic Surface,Q51
  6. Endoplasmic reticulum chaperone Calnexin / Calreticulin in G572R-hERG, E637K-hERG protein trafficking abnormalities role,R541.7
  7. Expression, Refolding and Purification of rHIV-1 Vif 158,R373
  8. Preparation and Application of Biological Macromolecules Imprinted Polymers for Lysozyme and BSA,O631.3
  9. Studies on the Mechanism of Two-state and One-state Protein Folding,Q51
  10. Protein folding liquid chromatography is used to restore denatured bovine insulin folding behavior,Q51
  11. New guanidine protein folding chromatographic stationary phase synthesis and the refolding of rhG-CSF purification of,O657.72
  12. Folding Kinetics of Two-state Proteins Based on Random Walk Model in Native Contacts Number Space,Q51
  13. Study on Protein Folding by Complex Network,Q51
  14. The Impact of ATPase Activity to the Function of Chaperonin from Sulfolobus Solfataricus P2,Q93
  15. Research of Protein Folding Based on Intelligent Algorithm,Q51
  16. Prediction of Protein Folding Based on Improved Genetic Simulated Annealing Algorithm,Q51-3
  17. Mechanism of Enzyme Catalysis and Protein Folding,Q55
  18. 1IZ2_A protein In chronic hepatitis B in progress preliminary study,R512.62
  19. The Refolding of RNase A with Dual-functional Stationary Phase and Initial Scanning of Active Component in Cord Blood Serum,Q503
  20. Refolding and Simultaneous Purification of the Recombinant Human Flt3 Ligand by Protein Folding Liquid Chromatography,Q78

CLC: > Industrial Technology > Automation technology,computer technology > Computing technology,computer technology > General issues > Theories, methods > Algorithm Theory
© 2012 www.DissertationTopic.Net  Mobile