Dissertation > Excellent graduate degree dissertation topics show

A Analysis on the Related Factors and the Therapeutie Effect of Chemotherapy-induced Liver Disease in Childhood Acute Lymphoblastic Leukemia

Author: JiaLiZuo
Tutor: ZhangBaoZuo
School: Hebei Medical University
Course: Pediatrics
Keywords: Chemotherapy Liver injury Leukemia Acute Lymphocytes
CLC: R733.71
Type: Master's thesis
Year: 2011
Downloads: 32
Quote: 0
Read: Download Dissertation

Abstract

Objective: To evaluate children with acute lymphoblastic leukemia chemotherapy, the incidence of liver injury and related factors; analysis of chemotherapy, the prognosis of liver injury and clinical efficacy observed hepatoprotective drug treatment of chemotherapy liver injury. Methods: A retrospective analysis of the Second Hospital of Hebei Medical University pediatric admitted from January 2005 to December 2010, 61 cases of acute lymphoblastic leukemia in children, including chemotherapy before liver injury in children except chemotherapy in the diagnosis of liver injury standard reference to the 1990 Conference of the European drug developed diagnostic criteria for drug-induced liver damage. The design cases excerpt tables, excerpts of each of the children with clinical manifestations, gender, age, risk classification, chemotherapy, and the degree of liver injury, in the presence or absence of infection during chemotherapy and transfusion history and liver injury with or without application of liver protection drugs its prognosis. Statistical analysis of the results: chemotherapy, the overall incidence of liver injury and chemotherapy degree of liver injury constituent ratio; different gender (including men and women in the two groups), age (including lt; 10 years and ≥ 10 years of age the two groups), different risk of type (including low-risk, medium risk and high risk group), the different chemotherapy phase of chemotherapy (including remission induction and consolidation therapy, extramedullary prevention, early intensive maintain strengthen stage) the extent of the similarities and differences of liver injury incidence and liver damage; treatment infection and transfusion in patients with chemotherapy liver injury incidence and liver damage degree of the difference in the application of liver protection drugs and hepatoprotective drug is not used (not hepatoprotective drug in children are mild liver damage in patients after chemotherapy liver injury ) on the prognosis of any differences. Statistical analysis: The results are statistically analyzed using statistical software SPSS13.0, the difference between the incidence of liver injury among the groups using χ2 test, P lt; 0.05 difference was statistically significant. Results: 1 chemotherapy of children with clinical symptoms and signs of liver injury occurred less obvious, only a few showed fatigue (nine cases), anorexia (n = 5), nausea (3 cases), mild (6 cases), jaundice and liver swelling (1 case), No ascites children found. 49 cases to 261 cases of acute lymphoblastic leukemia in children with chemotherapy, liver damage, chemotherapy liver injury was 80%, including 23% of liver injury incidence of mild chemotherapy, 39% of the chemotherapy, the incidence of moderate hepatic injury, severe chemotherapy 18% of the incidence of liver injury. 361 patients were boys of 37 cases, 24 cases of girls, the difference between the two sets of chemotherapy liver injury incidence no statistically significant differences (P gt; 0.05), but the boys mainly moderate chemotherapy liver injury (45.95%), the girl (33.33%) with mild chemotherapy liver injury. All children lt; 10-year-old, 46 cases, 15 patients ≥ 10 years of age, two sets of chemotherapy liver injury incidence difference was not statistically significance (P gt; 0.05), which lt; 10-year-old moderate chemotherapy liver injury (39.13%), mainly mild chemotherapy liver injury (40.00%) and ≥ 10 years of age. Limited statistics, can not come to the chemotherapy, the incidence of liver injury differences between the different risk typing any two groups merged and compare the difference was no statistical significance (P gt; 0.05). 6 different chemotherapy stage liver injury incidence differences (P lt; 0.05), after compared between the groups and found consolidate treatment stage than any other stage of chemotherapy to chemotherapy significantly lower incidence of liver injury (P lt; 0.005). Infection occurred in seven courses of chemotherapy, blood transfusions increase the chemotherapy, the incidence of liver injury (P lt; 0.05). 8 Application the hepatoprotective drug and unused the liver drug chemotherapy liver injury prognosis significantly different (P lt; 0.05). Conclusion: 1 pediatric ALL chemotherapy liver injury incidence, which mainly moderate chemotherapy liver injury and its clinical manifestations and signs are less obvious. The 2 chemotherapy liver injury incidence and the patient's age, gender, risk typing and other factors no significant differences, but chemotherapy degree of liver injury. The three chemotherapy concurrent infection risk factors for chemotherapy liver injury, chemotherapy, blood transfusions are also associated with chemotherapy liver injury. 4 chemotherapy after liver injury prognosis is usually good application of the the hepatoprotective drug can significantly increase the cure rate of chemotherapy liver injury.

Related Dissertations

CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms > Leukemia > Acute leukemia
© 2012 www.DissertationTopic.Net Mobile