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To Study the Exspressions of TOPOII, ERCC1, MDR1, PTEN and Livin in Epithelial Ovarian Cancer and Evaluate Their Clinical Significance

Author: LiuFang
Tutor: ZhangHui
School: Hebei Medical University
Course: Obstetrics and Gynaecology
Keywords: epithelial ovarian cancer factors for prognosis drug fast related gene chemotherapy resistance χ2 test log-rank test
CLC: R737.31
Type: Master's thesis
Year: 2011
Downloads: 95
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Abstract


Objective: TO study the expressions of TOPOII,ERCC1,MDR1,PTEN and Livin in the epithelial ovarian cancer tissues.TO evaluate the relationship between their expressions and pathologic type,operation-pathological stage,histological grade,chemotherapy resistance and the prognosis of epithelial ovarian cancer.Methods: To analyze retrospectively the clinical information of 81 patients with epithelial ovarian cancer.SPSS 13.0 software package was used. Using Kaplan-Meier method to calculate Survival rates and draw survival curve. Univariate analysis between different Survivorship rates was estimated by log-rank test. Multiple regression analysis were assessed by Cox proportional hazards model. Dependablity analysis was estimated by Spearman rank correlation. Enumeration data were compared withχ2 test.A statistically significant difference was indicated by P<0.05.Results:1 There are significant differences in histological type between the different age groups (P<0.05). The≥55 group has well differentiated,while the <55group has countrary results.2 Univariate analysis revealed that the expressions of TOPOII and ERCC1,treatment modality,operation circumsciption are significantly associated with the overall-survival of patients in epithelial ovarian cancer. The prognosis of the patients who have high expressions of TOPOII and ERCC1,enforced operation associated with chemotherapy and have exterminated tumor cell and lymph node cleaning operation are better.Multivariate analysis revealeds that pathologic type,operation- pathological stage,histological grade,expressions of drug fast related gene TOPOII,ERCC1, MDR1,PTEN and Livin,lymph node cleaning,lymph node metastasis, operation circumsciption,treatment modality are not independent risk factors for the prognosis of epithelial ovarian cancer.3 Relationship between drug fast related gene and pathologic type, operation- pathological stage,histological grade,chemotherapy resistance of epithelial ovarian cancer.There are no significant differences in the expressions of drug fast related gene TOPOII,ERCC1,MDR1,PTEN,Livin between chemotherapy resistance group and chemotherapy Sensitive group(P>0.05).And there are no significant differences between their expressions and different pathologic type,operation-pathological stage,histological grade(P>0.05).4 Comparison of various clinicopathologic factor related to lymph node metastasis,there are not significant differences in age,histological grade,pathologic type,operation-pathological stage(P>0.05).5 Correlation between the expressions of these drug fast related geneThe expressions between TOPOII and ERCC1 shows negative correlation(r=-0.447,P<0.001),the expressions between TOPOII and MDR1 shows negative correlation(r=-0.159,P<0.05),the expressions between TOPOII and PTEN shows negative correlation(r=-0.775,P<0.001),the expressions between TOPOII and Livin shows negative correlation(r=-0.476,P<0.001);the expressions between ERCC1 and MDR1 shows positive correlation(r=0.322,P<0.001);the expressions between ERCC1 and PTEN shows negative correlation(r=-0.404,P<0.001);the expressions between ERCC1 and Livin shows no correlation(r=-0.037,P=0.636>0.05);the expressions between MDR1 and PTEN shows negative correlation(r=-0.681,P<0.001 ) ;the expressions between MDR1 and Livin shows negative correlation(r=-0.456,P<0.001);the expressions between PTEN and Livin shows positive correlation(r=0.369,P<0.001).Conclusion:1 Histological grade is correlated with the patient’s age in epithelial ovarian cancer,when the patient’s age is lower,the histological grade is worse.2 The expressions of TOPOII and ERCC1,treatment modality,operation circumsciption are correlative risk factors for the prognosis of epithelial ovarian cancer.3 Pathologic type,operation-pathological stage,histological grade,expressions of drug fast related gene TOPOII,ERCC1,MDR1,PTEN and Livin, lymph node cleaning,lymph node metastasis,operation circumsciption,treatment modality are not independent risk factors for the prognosis of epithelial ovarian cancer.4 Expressions of drug fast related gene TOPOII,ERCC1,MDR1,PTEN and Livin are not significantly correlated with the pathologic type, operation- pathological stage,histological grade and chemotherapy resistance of epithelial ovarian cancer.5 Histological grade,age and pathologic type are not risk facors for lymph node metastasis in epithelial ovarian cancer.6 In epithelial ovarian cancer,the expressions between TOPOII and ERCC1, MDR1,PTEN,Livin shows negative correlation;the expressions between ERCC1 and MDR1 shows positive correlation;the expressions between ERCC1 and PTEN shows negative correlation;the expressions between ERCC1 and Livin shows no correlation;the expressions between MDR1 and PTEN,Livin shows negative correlation;the expressions between PTEN and Livin shows positive correlation.The different expressions of TOPOII,ERCC1,MDR1,PTEN and Livin may produce a cooperation or antagonistic effect with the development of epithelial ovarian cancer tissues.

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Ovarian tumors
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