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Silver Levin soup Professor mentor Valley Xiaohong treatment of children with exogenous experience side, the parties proceed from the lung and stomach Tongzhi theory, clinical pediatric cough, recurrent respiratory tract infection, achieved good results for the treatment of pneumonia and other lung diseases. In this study, based on the successful replication food product model's, research silver Levin soup on food product of animal influenza virus infection model of the therapeutic effect and mechanism, to further explore the party applications theory of experimental basis, and thus clear lung and stomach Tongzhi law on children with exogenous diagnosis and treatment clinical significance. The study is divided into two parts of the literature review, experimental study. Literature Review: discussed from three aspects: First, the use of traditional Chinese medicine theory from the physiological and pathological aspects of etiology and pathogenesis, therapeutic principle expounded correlation between the lung and stomach (intestinal), and lung and stomach Tongzhi law in lung diseases significance and role;, from the point of view of the micro-ecological investigate the correlation between the respiratory system and digestive system; Chinese and Western Medicine to two aspects of the cognitive theory of food product, experimental research and clinical overview. Experimental study: Objective: To explore the change of the food product is not the same phase mouse model of gastrointestinal function and lung injury, observation of the lung and stomach the Tongzhi Act of FM influenza virus infection of mice the efficacy of the food product, and gastrointestinal hormone, lung the influence of morphology, inflammatory injury, initially to investigate the mechanism of action. Method: Copy food product model, four days into normal group, normal 7-day group, food product 4-day group, food product seven days the group to study the factors of the food product on gastrointestinal function (EGG, serum gastrin, vasoactive intestinal peptide) impact; composite food product model infection model, divided into normal control group and infection group of the food product, food product is non-infection group, ribavirin group, Shuanghuanglian group of children of food pills, silver Levin soup high, medium and low dose group of nine, application ribavirin, Shuanghuanglian, children of food pills, silver the Levin soup high, medium and low-dose treatment of infection in mice after food product model, observation reflects the lung and stomach the Tongzhi Act of prescription the silver Levin soup mice infected with symptoms of lung morphology virus proliferation, blood cytokine expression impact on the food product. Results: ① food product model mice compared with normal controls coat color Chak eye secretions increase, eyes open, limited, constipation, yellow urine was oil granular abdominal distension; gastric electrical disorder showed a high frequency high spoke curve; Serum the gastrin was no significant difference in plasma vasoactive intestinal peptide, showing a rising trend. The ② Silver Levin soup low-dose group food plot the death of the mouse model of infection have some protective effect Shuanghuanglian oral children of food pills and silver Levin soup high, middle dose group of food plot infection model protective effect of death is not obvious; dual berberine, children of food pills, silver Levin soup dose, inhibition of pro-inflammatory cytokines IL-6 expression, there is a significant difference; children of food pills Silver Levin soup, each dose infection serum IL-10 content of the food product increasing trend, Shuanghuanglian group with food plot was no significant difference in the infection model group; children of food pills, silver Levin soup, low-dose, and Shuanghuanglian can reduce serum TNF-α levels in the food plot after infection, while silver Levin soup no difference in infection model group of the high-dose group and food product; Shuanghuanglian children of food pills, silver Levin soup high, medium and low dose serum IFN-γ infection food product can be elevated. Conclusion: Yangming heat card model, by food product as the cause of the formation of gastric electrical rhythm irregular internal environment disorder, gastrointestinal motility dysfunction; using lung and stomach the Tongzhi treatment exogenous animal model of the food product has a certain effect, and more single Qingwei Law and single Qingfei treatment is better, and pro-inflammatory cytokines and inhibiting inflammatory cytokine expression.
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