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Objective: To observe the clinical efficacy of Chinese medicine Qing management sputum detoxification combined western medicine treatment of severe Mycoplasma pneumoniae pneumonia. To explore its possible mechanism of action. Methods: in-patients met the inclusion criteria 62 patients were randomly divided into two groups, the test group and the control group of 31 cases each. 20 healthy children as a control group. The control group was given conventional western medicine of macrolides (azithromycin 10mg/kg.d); experimental group on the basis of conventional Western medicine treatment plus clothing the clear gold processing sputum detoxification square Chinese medicine, 2ml/kg.d, divided into morning and evening, 2 times a day orally ; two groups under the same conditions, the same western medicine, such as gender, age, duration and severity, no significant differences (P gt; 0.05), comparable. Normal group to the same period in our hospital examination no organic disease in healthy children of the same age group, nearly two weeks without infection, medication history, no other acute and chronic diseases, non-allergic and closely associated with the immune disease. The test group and the control group were admitted to hospital the next day and the treatment for two weeks after blood collection 2 times the normal control group, blood collection, blood specimens detect flow cytometry T cell subsets CD4, CD8 and CD4 / CD8 change; experimental group and the control group at the same time detect blood leukocyte count, C-reactive protein in two major inflammatory markers, abnormal white blood cell count in the real-time detection of the condition of patients in the observation process. Test group and the control group before the test and after two weeks of treatment based on symptoms, signs, certificates climate quantitative criteria to calculate the total score, calculated according to the total points overall clinical efficacy for treatment of two weeks of observation units. Time of the observations in the test group and the control group and the main symptoms disappear, complications, and white blood cell count abnormal recovery time for comparison. Results: 1 test and control groups before and after treatment, the overall efficacy comparison: the test group were cured, 30 cases markedly effective 0 cases, 0 ineffective; control group, 0 cases were cured, 25 cases markedly effective in 6 cases, invalid 0 cases. Between the two groups overall efficacy there is a significant difference (P lt; 0.05). Main symptoms disappeared after the treatment of symptoms before and after 2 test and control groups, signs, syndromes the quantified total score and treatment comparison: before treatment, symptoms, signs, syndromes quantify the total score was no significant difference (P gt; 0.05), with a comparable treatment group children; treatment of fever, cough, expectoration disappearance time was significantly less than that of the control group, the more significant difference (P lt; 0.05), especially fever difference more significant (P lt; 0.01) between the two groups. 3 test group compared with the control group inflammatory markers: blood leukocyte count between the two groups before treatment, C-reactive protein showed no significant differences (P gt; 0.05); After two weeks of treatment, C-reactive protein in the two groups was significant difference (P lt; 0.05), white blood cells no significant difference (P gt; 0.05), two sets of white blood cell count mean in the normal range, further were compared to blood system white blood cells there is a significant difference in recovery time (days) ( P lt; 0.05), the test group an average of two days less than the control group. 4 T cell subsets comparison: treatment before the test group and control group, CD4, CD8 and CD4/CD8 There was no significant sex difference (P gt; 0.05). Compared the two groups with normal CD4, CD4/CD8 significantly reduced, CD8 was significantly higher, statistically significant (P lt; 0.05). The test group after treatment CD4, CD4/CD8 was significantly higher, statistically significant (P lt; 0.05), CD8 decline, no statistical significance (P gt; 0.05). CD4 rise of the control group, statistical no significant difference (P gt; 0.05); of CD4/CD8 and elevated, CD8 decline was statistically significant (P lt; 0.05). Two treatment groups: experimental group CD4, CD4/CD8 increased more significantly, there is a significant statistical significance (P lt; 0.05), CD8 decline, statistically no significant difference (P lt; 0.05). 5 extrapulmonary complications comparison: test group of nine cases of pleural effusion, six cases of pleural effusion disappeared after treatment, three cases did not completely absorbed, and 66.7% efficiency; eight cases of the control group, three cases disappear after treatment, 5 cases of invalid efficiency of 37.5%; experimental group was significantly higher than that in the control group, but there was no statistically significant difference (P gt; 0.05). Test group of 15 patients with liver function impairment or myocardial damage returned to normal after treatment, 11 cases, 4 cases did not recover, and 73.3%; 17 cases of the control group, 10 patients recovered after treatment, seven cases recovery efficiency of 58.8% , the two groups was statistically no significant difference (P gt; 0.05). The 6 security indicators adverse comparison: trial group no adverse reactions during clinical observation. Three cases the treatment of early gastrointestinal reactions are self-healing in the control group. Treatment during the observation of the two groups of children with red blood cells, hemoglobin, platelets, alanine aminotransferase, blood urea nitrogen, urine will routine security indicator does not appear normal before treatment, after treatment, turn a different phenomenon. Prompted both groups have good security, plus with clear management sputum detoxification in order to reduce the side effects of Western medicine poison. Conclusion: 1 in Integrative Medicine (clear the gold management sputum detoxification square Combined with Western azithromycin) in the treatment of severe pneumonia Mycoplasma pneumonia as a whole is better than western medicine alone. The clear gold processing sputum detoxification combined Western medicine treatment of pneumonia mycoplasma pneumonia can alleviate symptoms and shorten the course, reduce macrolide drug resistance and drug side effects. 2 the clear gold processing sputum detoxification square has Qingrejiedu of Lifei cough, Xiefei, diuresis the role of its mechanism of action may be through the modulation of immune play a role, this study shows clear the gold management sputum detoxification can only improve significantly due to mycoplasma infection The decline of CD4, CD4/CD8 levels, T-cell subsets of the disorder to be corrected in a timely manner, thereby weakening the inflammatory response through strong immune injury caused by immune imbalances, strengthen the therapeutic effect. 3 gold processing sputum detoxification price is inexpensive, simple to use, no significant side effects have considerable clinical advantage in Treating severe mycoplasma pneumonia.
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