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The Application of Multifunctional Nanoparticles on Magnetic Resonance Imaging and Their Use for Cancer Cell Detection

Author: DaiXueYong
Tutor: ZhuLongZhang
School: Shanghai Normal University
Course: Physical and chemical
Keywords: Magnetic resonance imaging MRI contrast agent Magnetic separation Magnetic nanoparticles Cancer detection
CLC: TB383.1
Type: Master's thesis
Year: 2011
Downloads: 163
Quote: 1
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Abstract


Since the 1960s, nanotechnology has experienced rapid development in just a few decades. Nanotechnology refers to the nanometer scale (1 ~ 100nm) to study the properties of the substance, as well as utilize these characteristics multidisciplinary science and technology, it is the human understanding and transformation of the material world, the means and ability to extend to the atomic and molecular level. Nanomaterials development starting from the 1980s, functionalized nanomaterials, and life sciences Nanobiotechnology combined to produce the hot topic of people competing research to nano-material with magnetic resonance imaging technology The study is the most popular. Magnetic resonance imaging (magnetic resonance imaging, MRI) technology is one of the important molecular imaging technology, since its inception in 1973, has strong function, no damage and perfect anatomical image detail soft tissue characteristics of much biomedical of all ages, and is now one of the essential and vital tool in the clinical diagnosis. With the rapid development of nano-materials science in recent years, new types of MRI contrast agents (contrast agent) continue to emerge, adding a new force for the development of magnetic resonance imaging technology, one of the most widely used, the most representative is super The paramagnetic iron oxide particles such nano-particles, its small size, superparamagnetic, uniformity, stability and biocompatibility characteristics, Be the Investigator preferred in medical NMR imaging is an excellent contrast agent. In addition, nanomaterials has good magnetic properties, magnetic separation in cells highlights a good advantage in the external magnetic field, the functionalized magnetic nanoparticles can be modified quickly and effectively targeted content in the enriched blood cells rare cancer cells, so as to achieve the purpose of easy detection. The paper mainly multifunctional magnetic nanoparticles as targeted contrast agents in terms of application of magnetic resonance imaging of the tumor cells as well as in the blood of tumor cell enrichment and detection Exploration. (1) the use of chemical coprecipitation method dextran coated γ-Fe2O3 magnetic nanoparticles were characterized by XRD, IR, TEM, VSM particle characterization. The particle surface by chemically coupling biomolecules antibody marker for lung cancer cells, Prussian blue staining and MRI in T2 decreased values ??were measured antibody ligation efficiency; MTT method was used to test the the low concentrations versatile immune magnetic particles to enter cells 48 hours after cell viability, concluded that low concentrations of particles on cytotoxic cells and then a series of low concentrations of immune particle into an MRI test results show that low concentrations of γ-Fe2O3 magnetic nanoparticles can be good negative enhancer as lung cancer cells targeted contrast agent. (2) using the reverse microemulsion prepared silica-coated magnetic nanoparticles, and by chemical modification with biological activity of the amino-functional group, connected to the surface of the magnetic nanoparticles and biological molecules by the action of the crosslinking agent makes it antibody connection targeting to lung cancer cells, methods to establish rapid and effective separation and detection of trace amounts in the blood of cancer cells by magnetic separation, the detection limit can reach about 50 cancer cells to collect cells, about 25 50% enrichment efficiency in this The early diagnosis of lung cancer provides a fast and sensitive detection method.

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