Dissertation > Excellent graduate degree dissertation topics show

Synthesis of Fullerene Derivatives and Its Application in Electrochemical Sensing Analysis

Author: ShiJuanLan
Tutor: GaoFei；WangQingXiang
School: Zhangzhou Normal University
Course: Analytical Chemistry
Keywords: DNA electrochemical sensors C60 pyrrolidine derivatives Fullerenols Synthesis and Characterization
CLC: O621.3
Type: Master's thesis
Year: 2011
Downloads: 35
Quote: 0
Read: Download Dissertation

Abstract


The chemical modification of fullerenes has been one of the main areas of the fullerene research. Synthesized by chemical modification, a fullerene derivative having special properties and functions to expand the application fields of the fullerene having an important significance. In reaction of fullerene many, 1, 3 - dipolar cycloaddition reactions and fullerene hydroxylation has been widely used in the synthesis of functional fullerene derivative. The papers from C 60 derivatives synthesis, isolation, characterization and DNA electrochemical sensing analysis is an exploratory study, the main contents are as follows: to the C 60 < / sub>, of phthalaldehyde and L-threonine as raw material by 1, 3 - the dipolar cycloaddition synthesized and isolated 2 - (4 - formyl-phenyl) -5 - (1 - Hydroxyethylpuerarin yl) the C 60 pyrrolidine two isomers, respectively C 60 -CHO I and C of 60 -CHO II; using FTIR 1 H NMR the MS n (n = 1, 2, 3) and UV-Vis and other means products were characterized, its molecular formula is C 71 H 13 NO 2 , and fluorescence and electrochemical properties. C 60 -CHO I-modified glassy carbon electrode surface, and the use of a condensation reaction between an aldehyde group and an amino group, the covalent probe DNA fixed to the C 60 - CHO I modified glassy carbon electrode surface, and build a new type of electrochemical DNA sensors. [Fe (CN) 6 ] 3-/4- electroactive probe, using electrochemical impedance spectroscopy transgenic plants CaMV35S promoter Gene Fragments for quantitative detection mol / L, the detection range of 1.0 × 10 -13 1.0 × 10-9 mol / L, the detection limit of 1.5 × 10 -14 , and the sensor has a good selectivity. In addition, the C 60 -CHO II coating the surface of the glassy carbon electrode (GCE), the immobilization and hybridization of DNA probes. Application of electro-active substances methylene blue (MB) hybridization indicator, the fragment of the the CaMV35S promoter gene characteristics quantitative determination of the differential pulse method, the detection range of 1.0 × 10-15 1.0 × 10-9 mol / L, a detection limit of 4.0 × 10 -16 mol / L, the sensor can identify complementary DNA sequence and base mismatch sequence. In addition, tetrabutyl ammonium hydroxide as phase transfer catalyst, the the C 60 toluene solution with NaOH aqueous solution prepared by reacting a water-soluble fullerenols and use the nano effect fullerols and multiple active hydroxyl group, to build a 3D three-dimensional structure of the novel DNA sensor. The application chronocoulometry investigated Fuller alcohol modified electrode probe DNA (S1 fixed amount of 2.24 × 1013 (molecules / cm 2 )). By cyclic voltammetry and electrochemical impedance high sensitivity measurement of the target sequence, the detection range of 1.0 × 10 -15 1.0 × 10 - 9 mol / L, the detection limit of 1.7 × 10 -16 mol / L, and the electrochemical sensor has good selectivity and stability.

Related Dissertations

  1. Synthesis and Characterization of Novel Xanthene-containing Poly (Aryl Ether Ketone)s and Poly (Aryl Ether Sulfone)s,O633
  2. Design and Synthesis of Novel Pyrimidinoxyphenoxypropionate Compounds,O626
  3. Study on Synthesis of Gold Nanoparticles and Its Application in Cosmetics,TQ658
  4. Studies on the Synthesis, Characterization, and Antibacterial Activity of 2-aminoterephthalic Acid Schiff Base Coordination Polymers,O631.3
  5. Studies on the Synthesis, Characterization, and Biological Activity of the 2-amine-5-methylpyridin Schiff Base Complexes,O626.32
  6. Synthesis and Properties of Novel Aromatic Polyamides Containing Bulky Xanthene and Trifluoromethyl Pendants,O633.22
  7. Synthesis and Properties of Perylene Bisimides Containing Benzocyclobutene Groups for Organic Light-emitting Diodes,O621.25
  8. Studies on Synthesis, Characterization and Adsorption Performance of Crosslinked Cassava Starch Microspheres,TS236.9
  9. Study on the Synthesis and Properties of New Materals and Their Application in Electroanalytical Chemistry,O621.2
  10. Synthesis and Characterization of Novel Polyarylates Containing Xanthene Units,O633.5
  11. Synthesis and Characterization of Novel Polyimides Containing Xanthene Groups,O633.22
  12. Synthesis、Characterization and Acaricidal Activity of Mixed Trialkyltin Compounds Containing Silicon,TQ450.21
  13. The Synthesis of 2-Alkoxy-N~6-Alkyl Adenosine Compounds and Their Anti-Platelet Aggregation Activity,R96
  14. Synthesis Characterization and Research of Fluorescence Properties in Binary and Trinary Systems of Rare Earth Perchlorate with Acetophenonylcarboxymethyl Sulfoxide,O627.3
  15. Electrochemical Synthesis and Characterization of Tantalum and Niobium Alkoxides,TN304.05
  16. Research on the Technology of Self-Assembling Cyclopeptide Nanotubes,TB383.1
  17. 5,6 1,10 - phenanthroline modified compound synthesis,O641.4
  18. Design , synthesis and characterization of metal - melon ring skeleton complexes,O641.3
  19. Synthesis, characterization , and solution coordination chemistry of new Schiff base compounds,O621.13
  20. Synthesis and Photocatalytic Properties of Metal-tetra(1, 4-dithiin)porphyrazine Bearing Peripheral Tetrapropyl-bromine,O627
  21. Synthesis and Characterization and Adsorptive Property Research on Arsenic of Hydrated Ferrous Oxide-loaded Resin,TU991.2

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Synthetic organic chemistry
© 2012 www.DissertationTopic.Net  Mobile