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Magnetic thermosensitive hydrogel preparation and application

Author: WeiYaChao
Tutor: LiuZuoYang；ZhangDanCan
School: Hebei North University
Course: Pharmacology
Keywords: Magnetic Nanoparticles PLGA-PEG-PLGA Block copolymer Temperature-sensitive Hydrogel Micelles Troxerutin In vitro release
CLC: R943
Type: Master's thesis
Year: 2011
Downloads: 102
Quote: 0
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Abstract


In order to achieve pulsatile release anticancer drugs to reduce the frequency of administration, improve the therapeutic effect, reduced toxicity, and this paper was prepared containing magnetic nanoparticles of PLGA-PEG-PLGA thermosensitive hydrogel. The drug-containing magnetic thermosensitive hydrogel injected into the body, you can make use of alternating magnetic field of its diplomatic body temperature control, then control the drug release them in accordance with the patient's condition requires pulse release. This topic examines the magnetic thermosensitive hydrogel varying magnetic field in the diplomatic body temperature performance, and investigated with PLGA-PEG-PLGA thermosensitive hydrogel as a carrier to troxerutin as a model drug delivery system in vitro under different temperatures release situation, hoping to provide a basis for further research. Issue is the major specific contents and conclusions are as follows: a temperature-sensitive hydrogel Synthesis and Characterization of Racemic lactide (D, L-lactide), glycolide (glycolide) and PEG as raw materials, different stannous octoate as catalyst, using the ring-opening polymerization, by changing the feed ratio and the molecular weight of PEG, PLGA-PEG-PLGA prepared block copolymer. By NMR (1HNMR) and infrared spectroscopy (FTIR) to determine the composition and structure of the copolymer; gel permeation chromatography (GPC) average molecular weight of the copolymer was determined and the molecular weight distribution; rewind tube measured phase transition temperature of the copolymer solution and precipitation temperature; senior with Anton Paar rheometer effects of different copolymer rheology; dynamic light diffraction method (DLS) particle size measurement copolymer micelles and Zeta potential; transmission electron microscopy (TEM) observation micelles The morphology. The results showed that: the product was a target product PLGA-PEG-PLGA triblock copolymer relatively pure, stable, molecular weight distribution; copolymer solution at a concentration range of the solution can occur - gel - precipitation change, the phase change temperature can be By changing the feed ratio and the molecular weight of PEG to adjust; rheological investigation also showed that the copolymer has a temperature-sensitive; copolymer micelle diameter (LA: GA: PEG1500 = 6:1:3) at 35 nm or so, and can be seen through the DLS and TEM micelle size distribution; micelles Zeta potential at -6.15 mV or so. Two magnetic thermosensitive hydrogel magnetic fluid heating performance will join PLGA-PEG-PLGA aqueous solution was investigated magnetic fluid on the copolymer solution Thermosensitivity impact; and then put it into an alternating magnetic field, the magnetic fluid concentrations were investigated and current on the warming effect. The results show that the magnetic fluid is added to the temperature-sensitive hydrogel, no change in temperature sensitive hydrogels original temperature sensitivity; magnetic thermosensitive hydrogels alternating magnetic field, the heating of the magnetic fluid concentration and the alternating magnetic field current of a linear correlation (r values ??were greater than 0.97), we can change the concentration of magnetic fluid and alternating field current to achieve the system temperature control 3 g rutin in vitro release investigation troxerutin thermosensitive hydrogel for temperature-sensitive effects ; selection phase transition temperature is 25 ℃ of PLGA-PEG-PLGA as a carrier troxerutin as a model drug, the physical mixing method copolymer concentration of 20% (w / w) drug-containing gel, using no film dissolution model Studies in vitro under different temperatures (40 ℃ and 30 ℃) the release behavior. The results showed that the addition troxerutin thermosensitive hydrogels for thermosensitive little effect; By changing the PLGA-PEG-PLGA thermosensitive hydrogel temperature can change the speed of their release. In summary, the subject of building a new magnetic thermosensitive PLGA-PEG-PLGA hydrogel can be used as anticancer drugs and other drugs carrier, through the diplomatic body magnetic field can be achieved pulsatile release of drugs to meet the cancer patient's condition needs.

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