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The Study of Pharmacokinetic Mechanism on the Treatment of Bacterial Prostatitis by Α1 -Adrenoceptor Blocking Drugs Combined with Antibacterial Drugs

Author: ZengYang
Tutor: XiaoMingChao
School: Chongqing Medical University
Course: Surgery
Keywords: alpha1 - receptor blockers Antimicrobial drugs Bacterial prostatitis Pharmacokinetic Mechanism
CLC: R969.1
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
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Abstract


Objective To investigate the oral alpha 1 < / sub > - blockers combined bolus antimicrobial treatment of bacterial prostatitis in rats , the former on the latter in the prostate tissue medicine pharmacokinetic . The constructed bacterial prostatitis rat model of 120 , were randomly divided into experimental and control groups . Two groups of animals intravenous bolus injection of levofloxacin solution ( 44mg/kg ) , the experimental group fed with terazosin hydrochloride solution ( 0.44mg/kg ) , control group fed with solvent . Animal prostate tissue made ??into tissue homogenates were collected after the administration 1,3,7.5,15,30,60,120,240,480 and 720min HPLC method for the determination of the concentration of levofloxacin in the various tissues , 3P97 software to calculate the pharmacokinetic parameters of . Tamsulosin ( 0.018mg/kg ) replace terazosin after repeated experiments . Concentration-time curve of the experimental group and the control group in the administration of terazosin levofloxacin are in line with the two-compartment model , the main pharmacokinetic parameters were as follows : t ? Beta ( 6.57 ± 2.73 ) and ( 2.11 ± 0.72 ) h ; t < sub> max ( 0.34 ± 0.08 ) and ( 0.64 ± 0.18 ) h ; the C max , respectively (149.41 ± 41.16) and ( 72.26 ± 23.26 ) microg / g ; CL respectively ( 0.07 ± 0.02 ) and ( 0.20 ± 0.06 ) g / h ; AUC0 - 12 were (608.02 ± 226.82) and ( 253.67 ± 91.68 ) mg · h · g -1 < / sup > . More than two groups of animals , each parameter has a significant difference ( P lt ; 0.01 ) . Experimental group and the control group, drug administration tamsulosin curve is also in line with the two-compartment model , the main pharmacokinetic parameters were as follows : for t 1/2β , respectively ( 5.91 ± 1.81 ) and ( 2.87 ± 0.98 ) h; t max ( 1.08 ± 0.22 ) and ( 1.00 ± 0.13 ) h ; the C max ( 30.02 ± 4.57 ) and ( 22.05 ± 3.36 ) microg / g ; CL ( 0.23 ± 0.04 ) and ( 0.51 ± 0.02 ) g / h ; AUC ?? 0-12 < / sub > , respectively ( 170.25 ± 17.39 ) and ( 93.74 ± 9.11 ) mg · h · g -1 , where t 1/2β < / sub > , C max < / sub > , CL and AUC 0-12 of the parameters have significant difference ( P lt ; 0.05 ) . Conclusion the alpha 1 < / sub > - blockers can significantly increase the drug concentration of antimicrobial drugs in prostatitis tissue , extended half-life and reduced clearance rate , so that the effective concentration of antimicrobial agents time .

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CLC: > Medicine, health > Pharmacy > Pharmacology > Journal of Clinical Pharmacology > Pharmacokinetic
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