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Armillarisin prevention of cisplatin -induced gastrointestinal reaction mechanism of

Author: DuJing
Tutor: LiPing
School: Anhui Medical University,
Course: Geriatrics
Keywords: Armillarisin EGG 5-HT Vomit Experimental study
CLC: R730.5
Type: Master's thesis
Year: 2011
Downloads: 29
Quote: 1
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Abstract


Objective: To evaluate Armillarisin cisplatin (DDP) during chemotherapy-induced gastrointestinal reactions control effect. Explore the exogenous Armillarisin cisplatin resistance (DDP) during chemotherapy concurrent gastric smooth muscle electrical activity and 5-HT content and the relationship between changes. Methods: 48 male SD rats were randomly divided into six groups: control group, model group, Armillarisin low, medium and high dose group and the ondansetron group, intraperitoneal injection of cisplatin chemotherapy manufacture nausea pica in rats vomiting model was Armillarisin rat kaolin intake, feed intake, water intake and body weight. 90 male SD rats were randomly divided into six groups: control group, model group, Armillarisin low, medium and high dose group and ondansetron group, referring to De Jonghe France to 6 mg / kg body weight by intraperitoneal injection DDP manufacturing pica in rats chemotherapy nausea and vomiting model, using Biopac dedicated gastrointestinal electrical recording and analysis system to detect antral smooth muscle electrical activity detected by ELISA using rat brain and gastrointestinal 5-HT content was observed to DDP replication model armillarisin different time periods after gastric electrical activity and 5-HT content and its relationship between the two. Results: After modeling 24h, 48h and 72h, Armillarisin high dose group and ondansetron kaolin intake of rats were significantly lower than the model group (P lt; 0.05); After modeling 48h, 72h of feed intake, water intake, and body weight 72h after modeling three indicators Armillarisin middle dose group were significantly higher than the model group (P lt; 0.05), while the ondansetron group and model group were not statistically significance (P gt; 0.05). After modeling 24h ~ 72h, model rats gastric slow wave frequency per minute (CPM) and mean amplitude (AV) were significantly higher than the control group (P lt; 0.05) bacteria with bright, high-dose group (P lt; 0.01), in order to 24h after modeling, model group (CPM: 7.33 ± 2.92, AV: 249.75 ± 79.09) compared with the control group (CPM: 3.00 ± 1.55, AV: 148.04 ± 63.51), Armillarisin high doses (CPM: 4.13 ± 1.14, AV: 163.46 ± 26.14) The most obvious difference; modeling after 24h ~ 72h, Armillarisin high dose rats kaolin intake were significantly lower than the model group (P lt; 0.05), which made 24h after model Armillarisin middle dose group, after modeling 24h, 48h, 72h Armillarisin the high dose group and gastric duodenal tissue 5-HT levels were significantly lower than the model group (P lt; 0.01), while the medulla oblongata tissue 5-HT content showed only after modeling 24h Armillarisin high dose group was significantly lower than the model group (P lt; 0.05); antrum CMP and AV overall trend with an increase in 5-HT content increased, especially in the modeling 24h after the most obvious trend. Conclusion: bright bacteria can effectively inhibit cisplatin induced pica reaction Armillarisin middle dose group in cisplatin-induced decrease feed intake, water intake and weight reduction reduce three aspects of the improvement of gifted in less ondansetron group. Tabescens rats after chemotherapy to reduce gastrointestinal tissue release of 5-HT, can effectively inhibit the DDP chemotherapy induced gastric rhythmic movement disorder, their stomach during chemotherapy-induced rhythmic movement disorder and the inhibition mechanism may be the regulation of 5-HT related.

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