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Clinical Significance of the Quantity of Tumor Associated Macrophages and the Expression of IL-6、IL-8 in Diffuse Large B-cell Lymphoma and Follicular Lymphoma

Author: TangMeng
Tutor: GuKangSheng
School: Anhui Medical University,
Course: Oncology
Keywords: Non-Hodgkin 's lymphoma Tumor microenvironment Tumor-associated macrophages IL-6 IL-8
CLC: R733.1
Type: Master's thesis
Year: 2011
Downloads: 95
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Abstract


Background and purpose of diffuse large B-cell lymphoma (Diffuse Large B-cell Lymphoma, DLBCL) and follicular lymphoma (follicular lymphoma, FL) is different from aggressive non-Hodgkin's lymphoma (non-Hodgkin's lymphoma, NHL) . They have each of the clinical characteristics and biological behavior may be due to the tumor microenvironment are closely related. CD68 is a surface antigen of the macrophage marker. The tumor-associated macrophages (Tumor associated macrophage, TAM) is an important component of the lymphoma microenvironment. Studies have shown that TAM interaction between tumor cells and stromal cells through the secretion of cytokines involved in tumor growth, invasion and metastasis. Therefore, by detecting the number of TAM and its secreted cytokine expression in DLBCL and FL tissue microenvironment, combined with the efficacy of chemotherapy, the survival of the follow-up and prognosis analysis, about the number of TAM and the secretion of cytokines expressed whether the correlation between the biological behavior between these two types of lymphoma. Methods January 2000 - December 2008, the First Affiliated Hospital of Anhui Medical University, Department of Medical Oncology admitted pathological diagnosis clear and untreated FL patients 39 cases, 68 cases of DLBCL patients. By immunohistochemistry (SP method) were used to detect the number of tumor tissue in patients with TAM and IL-6, IL-8 of the expression. SPSS 13.0 statistical package for statistical analysis of the number of TAM and IL-6, IL-8 expression of DLBCL and FL term efficacy related to its the chemotherapy long-term survival of DLBCL. 1.68 cases of DLBCL patients, TAM number is not increased in 39 cases, chemotherapy effective rate of 94.9% CR rate was 66.7%. Increased the number of TAM group of 29 patients, the effective rate was 93.1% CR rate was 62.1%. TAM number of different groups of short-term efficacy was no significant difference (P gt; 0.05) 39 cases of FL patients, the TAM the number is not increased in the group of 32 patients, chemotherapy effective rate was 93.8% CR rate was 68.8%. Increased the number of TAM 7 patients, chemotherapy effective rate was 100.0%, CR rate of 57.1%. Increased the number of TAM CR rate downward trend, and the difference was statistically significant. DLBCL group increased the number of TAM cases significantly more than the FL group, and the difference was statistically significant (P lt; 0.05) 3.68 cases of patients with DLBCL survival analysis showed that TAM number is not increased in the group of MS is 36 months, the increased group MS was 17 months, the overall survival between the two groups statistically significant difference (P = 0.000). 4.68 cases of DLBCL patients, IL-6 expression in 47 cases (69.1%) and negative in 21 cases (30.9%). 39 cases of patients with FL, IL-6 expression in 16 cases (41.0%) and negative in 23 cases (59.0%). DLBCL and FL cases, the the TAM number increased IL-6 expression had no significant correlation (P gt; 0.05) Spearman rank correlation analysis. 5.68 cases of DLBCL patients, IL-8 expression in 38 cases (55.9%) and negative in 30 cases (44.1%). 39 cases of patients with FL, IL-8 expression in 15 cases (38.5%) and negative in 24 patients (61.5%). Spearman rank correlation analysis TAM increased the number of IL-8 expression was positively correlated (P lt; 0.05). 6 univariate survival analysis showed that increased the number of TAM, IL-8 were statistically significant prognostic factors; Cox proportional - risk model for multivariate analysis showed that IPI score, TAM number increased with the prognosis of DLBCL was negative related DLBCL independent predictor of survival (P lt; 0.05) Conclusion 1.TAM number DLBCL and FL were increased, and an increase in the number of TAM in DLBCL than FL increased significantly, may be related to the biological behavior of the tumor. The short-term effect of number of 2.TAM with FL TAM number of cases increased short-term effect of chemotherapy is poor, the CR rate. Number of 3.TAM and long-term survival in patients with DLBCL TAM number of cases increased median survival period is shorter, is an adverse prognostic indicators. The increase in the number of 4.TAM and IL-8 expression was positively correlated, suggesting that IL-8 in the TAM and tumor cell interactions play an important role. Of 5.IPI high rating and TAM increase in the number of negatively correlated with the prognosis of DLBCL, DLBCL independent predictor of survival. 6.TAM DLBCL and FL exact clinical value and TAM by cytokines and tumor cell interactions in urgent need of large sample size, prospective clinical study to further verification.

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CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms > Reticuloendothelial system tumors
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