Dissertation > Excellent graduate degree dissertation topics show

Dynamic SPECT Imaging to Measure Liver Function Reserve Clinical Application and Research

Author: SunYongGang
Tutor: LiJianSheng；XuGeLiang；HuangQiang；JiaWeiDong；HuHeJie；MaJinLiang
School: Anhui Medical University,
Course: Surgery
Keywords: Liver dysfunction The diethyl ACETANILIDE iminodiacetic acid Liver function Region of interest
CLC: R735.7
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
Read: Download Dissertation

Abstract

[Objective] To explore technetium labeled diethyl acetanilide imino diacetate (technetium-99m labeled subdiethyl acetanilide ammonia diacetate, 99mTc-EHIDA) combined with single photon emission computed tomography imaging agent (single photon emission computed tomography, SPECT) scan to assess the feasibility of liver function, and put forward the indicator criteria. 2 to determine The SPECT, ICG15, Child-pugh classification which method is more accurate assessment of liver function. Method surgical resection from July 2009 to July 2010 46 patients with HCC clinical data analysis, the initial development of evaluation criteria, and evaluate which method is more sensitive. 1 2 days before surgery SPECT scintigraphy, statistical analysis of peak radiation count, to a peak time (min), 5 min darling the index (HLI5), cardiac clearance index (HH15), liver receptor index ( LHL15) and other indicators of liver dysfunction. Comparative analysis of the Child-Pugh classification, ICGR15, HH15 in assessing liver function, which method is more sensitive and analyze its specificity, sensitivity. [Results] 1. HH15 good group of postoperative liver function recovery and recovery of liver function insufficiency mean of 0.49 ± 0.08 and 0.59 ± 0.09, between the two groups were significantly different (P lt; 0.05). Intended 0.533 HH15 threshold (cut-off), the HH15 ≥ 0.533 patients the incidence of postoperative hepatic dysfunction HH15 lt; statistical difference between the incidence of 0.533 patients with postoperative liver dysfunction (χ ~ 2 = 12.03, P = 0.001). 3. HH15, ICGR15 and Child-pugh classification insufficiency of liver function and liver function recovery between good group, the only HH15 statistical difference (P = 0.004); HH15 predict the surgical liver dysfunction incidence sensitivity of 93.3 % and a specificity of 64.5%. 4 patients with hepatocellular carcinoma of liver resection is divided into three groups: less than or equal to a liver segment resection group A, larger than a liver segment, less than or equal to two hepatic segmental resection (group B), more than two-stage resection (group C) . HH15 lt; 0.533 patients among the three groups postoperative liver dysfunction incidence was not statistically significant (A, B can not be compared; A, C between x2 = 0.917, P = 1.000; B, C between chi ~~ 2 = 1.78, P = 0.375); in HH15 ≥ 0.533 patients, the A group and B group, the significant difference between group A and group C (chi to 2 = 7.20, P = 0.013; chi to 2 = 9.55 , P = 0.005), B and C groups was not statistically significant (chi to 2 = 0.83, P = 0.603). [Conclusion] 1 HH15 sensitive indicator to predict postoperative liver dysfunction incidence. The tentatively set the HH15 critical value of 0.533. 3 In the present study HH15 do not predict postoperative liver function lower incidence of ICGR15 and the Child-pugh classification more sensitive. Feasible 4. HH15 lt; 0.533 greater than two-stage liver resection; When HH15 ≥ 0.533 when the line is less than or equal to a segment liver resection safer line is greater than the period hepatectomy liver dysfunction incidence was significantly higher.

Dynamic SPECT Imaging to Measure Liver Function Reserve Clinical Application and Research

Abstract

Related Dissertations