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Tumor necrosis factor receptor 1 in hepatocellular carcinoma and its significance

Author: LiuQiaoYu
Tutor: WangHai
School: Nanjing Medical University
Course: Surgery
Keywords: Hepatocellular carcinoma Tumor necrosis factor receptor-1 Apoptosis
CLC: R735.7
Type: Master's thesis
Year: 2011
Downloads: 28
Quote: 0
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Abstract


Objective : To investigate the tumor necrosis factor receptor 1 (Tumor necrosis factor receptor 1, TNFR1) in hepatocellular carcinoma and its significance. Methods: Immunohistochemistry (SP method ) and Western Blot were used to detect 76 cases of hepatocellular carcinoma patients with tumor tissue and adjacent tissues TNFR1 protein expression , and by RT-PCR to detect the mRNA level . Results : TNFR1 expression in hepatocellular carcinoma positive rate ( 39.5% ) was significantly lower than the adjacent tissues (89.5%, P lt; O.05), and with an increase in tumor grade , TNFR1 in adjacent tissues amount increments ; Western Blot assay visible adjacent tissues TNFR1 protein expression was significantly higher than tumor tissue. TNFR1 mRNA at the gene level of 2 - △ △ Ct values ​​in adjacent tissues and cancer tissues as mean ± standard deviation, respectively, 0.0730 ± 0.020 and 0.0287 ± 0.0079 (P lt; O.05), is also able to authentication. Conclusion : TNFR1 -mediated apoptosis in hepatocellular dominant role in the development , TNFR1 expression enhancement and differentiation of hepatocellular carcinoma and closely related to the incidence of liver cancer development play an important role.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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