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Research on Expression of NK Cell Receptors/Ligands in Acute Leukemia Patients and Its Relationship with GVHD and Relapse after Haploidentical Hematopoietic Stem Cell Transplantation

Author: GeShuJing
Tutor: DuanLianNing；ZhaoZiGang
School: Hebei North University
Course: Pathology and Pathophysiology
Keywords: NK cell receptor Ligand Graft-versus- host disease Relapse Acute leukemia Haploid Hematopoietic stem cell transplantation
CLC: R733.71
Type: Master's thesis
Year: 2011
Downloads: 21
Quote: 0
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Abstract


The activating receptor NKG2D and inhibitory receptors NKG2A explore the natural killer cells (naturalkillercell, NKcell) in newly diagnosed acute lymphoblastic leukemia (acutelymphocyticleukemia, ALL) and acute myeloid leukemia (acutemyeloidleukemia, AML) patients with NK cells, CD3 ~ T differentially expressed in leukemia cells, the cells and the corresponding ligand major histocompatibility complex class I-related molecules A / B (majorhistocompatibilitycomplexclass Ⅰ-relatedchainA / B, MICA / B) and human leukocyte antigen E (humanleukocyteantigen-E, HLA-E) Graft versus host immunological significance, and study for the killer cells of the immune globulin-like receptor (killercellimmunoglobulin-likereceptors, KIR) ligand recipient mismatching haploidentical hematopoietic stem cell transplantation (haploidenticalhematopoieticstemcelltransplantation, haplo-HSCT) disease (graft-versus-hostdisease, GVHD) and disease recurrence occurs. Of the 30 cases detected by flow cytometry of 60 cases of patients with primary acute leukemia (ALL and AML) bone marrow of NKG2D and NKG2A NK cells and the expression levels of CD3 ~ T cells and the corresponding ligand MICA / B and HLA-E in acute The expression levels of leukemia cells, while retrospective analysis of 45 cases of Blood Diseases Branch of the Air Force General Hospital Transplant Center haplo-HSCT recipient KIR ligands for mismatching on GVHD and recurrence. Research results show that NK cells of ALL patients and of CD3 ~ T cells NKG2D and NKG2A positive expression rate compared with AML patients there was no significant difference (P gt; 0.05), but ALL patients with leukemia cells of MICA / B and HLA-E-positive expression rate were significantly higher than the AML patients (P lt; 0.05). 16 patients after Haplo-HSCT GVHD, the incidence rate of 35.6%, which occurred three cases of Ⅱ - Ⅳ degree aGVHD incidence of 6.7%. 10 patients, the recurrence rate was 22.2%. The donor and recipient HLA-Cw matched group and KIR matched group of acute graft-versus-host disease (acutegraft-versus-hostdisease, aGVHD), chronic graft-versus-host disease (chronicgraft-versus-hostdisease, cGVHD) and disease recurrence rates of less than its sub-groups; graft-versus-host (graftversushost, GVH) vector group aGVHD low incidence of cGVHD and relapse rate is higher than the non-GVH vector group. The 3-year survival analysis: below the sub-group matched group of HLA-Cw KIR matched group is higher than the sub-group, and the GVH vector group, slightly lower than the non GVH vector group. The study found differences of ALL and AML patients with immune cell function may depend on different leukemia cell ligand expression itself NK and T cells express killer inhibitory receptors. Haplo-HSCT for recipients of HLA-Cw consistency, KIR consistency may be associated with low GVHD in patients and low recurrence rate, and HLA-Cw substandard and KIR consistency may improve the survival rate of patients. KIR ligand mismatch may be related to a low of aGVHD high cGVHD occurrence and high recurrence rate, no significant effect of the 3-year survival rate.

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CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms > Leukemia > Acute leukemia
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