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Expression of Autophagy-Related Genes BECLIN1 and MAPLC3 in Invasive Pituitary Adenomas

Author: FengQingLin
Tutor: HuoGang
School: Chongqing Medical University
Course: Surgery
Keywords: Autophagy Beclin1 MAPLC3 Pituitary adenoma
CLC: R736.4
Type: Master's thesis
Year: 2011
Downloads: 36
Quote: 0
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Abstract


Objective: To explore the relationship between expressions of autophagy-related genes Beclin1 and microtubule-associated light chain protein 3(MAPLC3) in pituitary adenomas with its invasiveness.Methods: 61 specimens of pituitary adenomas were classified into invasive and non-invasive groups according to the comprehensive evaluation of invasive pituitary adenomas.The protein expressions of Beclin1 and MAPLC3 in the invasive and non-invasive groups were detected by immunofluorescence analysis and western blot, and their mRNA expressions were detected by RT-PCR.Results: 32 specimens of pituitary adenomas were invasive and 29 were non-invasive.The protein expressions of Beclin1 and MAPLC3 were significantly lower in invasive pituitary adenomas than that in non-invasive pituitary adenomas.Their mRNA expressions were lower in invasive group too.Conclusion: The expressions of autophagy-related genes Beclin1 and MAPLC3 are lower in invasive pituitary adenomas, which may relate to their invasiveness.

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CLC: > Medicine, health > Oncology > Internal endocrine tumors > Pituitary tumor
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