Dissertation > Excellent graduate degree dissertation topics show

Association Study of Genetic Polymorphisms in Serotonin System and Family Environment with Antisocial Personality Disorder

Author: WuYanFeng
Tutor: TanZuoAn
School: Nanjing Medical University
Course: Psychiatry and Mental Health
Keywords: Antisocial Personality Disorder 5-HT transporter Monoamine oxidase A Tryptophan hydroxylase 2 Family environment Impulsive behavior Single nucleotide polymorphisms Haplotype
CLC: R749.91
Type: Master's thesis
Year: 2011
Downloads: 68
Quote: 0
Read: Download Dissertation


Purpose of Antisocial Personality Disorder (Antisocial personality disorder, ASPD) role is well received by the occurrence of genetic factors, but also by environmental factors. This study is to determine the 5-HT transporter (5-Hydroxytryptamine transporter 5-HTT) and monoamine oxidase A (Monoamine oxidase A, MAOA) and tryptophan hydroxylase 2 (Tryptophan hydroxylase2, TPH2) gene 5 - hydroxytryptamine (5 -Hydroxytryptamine ,5-HT) system candidate genes for each mutant single nucleotide polymorphisms (Single nucleotide polymorphism, SNP), to explore the frequency of the mutant allele, genotype frequencies and haplotypes in patients and control groups The difference between the 5-HTT and MAOA gene interaction between, TPH2 gene family environment, to detect genetic markers of ASPD and its possible pathogenesis. Method ASPD 117 patients were male, aged 20-52 years old, the average age (31.31 ± 6.27) years; healthy control group, 142 cases were male, aged 20-50 years old, average age (32.81 ± 7.57) years old. Variable number of tandem repeats (Variable number of tandem repeats, VNTR) and polymerase chain reaction - restriction fragment length polymorphism (Polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP) assay 5-HTT, the MAOA rs1137070 and TPH2 rs4570625, rs4131347, rs4290270, rs7305115 gene polymorphism; using the Barratt Impulsiveness Scale (Barratt, Impulsiveness Scale-11, BIS-11) and the Family Environment Scale - Chinese version (Family Environment Scale-Chinese Version, the FES- CV) assessment impulse level and family environment; using SHEsis Software analysis TPH2 gene haplotypes. 1, the patient group BIS-11 total score, pay attention to factors and unplanned factor score was significantly higher (P lt; 0.05). Emotional expression of the patient group scored lower than the control group, contradiction success controlling score higher than that of the control group, the difference was statistically significant (P lt; 0.05). 2,5-HTTVNTR, MAOA rs1137070 genotype distributions are in line with the genetic balance law of (Hardy-Weinberg equilibrium, HWE), allele and genotype frequencies between the patient and control groups showed no significant sex; 5-HTT and MAOA gene polymorphism exists interaction. TPH2 rs4570625, rs4131347, rs4290270, rs7305115 each SNP genotype distribution are in line with HWE. rs4570625 genotype and allele frequencies between ASPD group and the control group the differences were statistically significant. The strength of the association analysis showed ASPD and GG genotype was positively associated [odds ratio (OR) = 1.458, 95% confidence interval (CI) = 1.080-1.968), with the G allele has also become a positive association (OR = 1.479,95% CI = 1.045-2.094). The other three-locus genotype and allele frequency distribution ASPD group and the control group, the difference was not significant. 4, TPH2 rs4290270 and rs7305115 allele pairing was haplotype TA, ASPD frequency was significantly higher than that of the control group, the difference was significant (χ to 2 = 6.177, P lt; 0.05), OR value of 1.865,95% CI as 1.135-3.065. Other haplotypes were no differences between the two groups was significant. 5, in accordance with the TPH2 rs4570625 genotype the ASPD patients BIS-11 score divided into three groups, with ASPD patients with GG genotype group BIS-11 total score and factor scores were (71.28 ± 7.50) min, (19.60 ± 3.41 ) points, (25.73 ± 4.92) min (25.95 ± 4.77) min] were higher than the GT genotype [(66.23 ± 8.06) points, respectively, (17.79 ± 3.02) min, (23.06 ± 3.84) min, (25.38 factor, motility factor and the difference was statistically significant (F lt; 0.05), and unplanned factor was no significant difference. Carrying G allele Group BIS-11 total score and factor scores [were (68.52 ± 8.17) points, (18.61 ± 3.31) min, (24.27 ± 4.54) min, (25.64 ± 4.86) min] were higher than those do not carry 6, according to whether TPH2 rs4570625 T allele genotype were divided into two groups (rs4570625T rs4570625T-group), expression of emotion in the family environment, success, morality, religion, and there is an interaction of four factors and TPH2 rs4570625 controlling role (P lt; 0.05), OR values ??were 1.122,0.843,1.080 0.880,95% CI of 1.043-1.206,0.747-0.951, 1.010-1.155 and 0.792-0.978. Emotional expression in the family environment, the TA haplotype Moral Religion 2 factor paired with the TPH2 rs4290270 and rs7305115 allele interaction (P lt; 0.05), the OR values ??were 1.122 and 1.080,95% CI 1.043-1.206 and 1.010-1.155. Conclusion 5-HTT, MAOA gene polymorphism with ASPD was no significant correlation ,5-HTT and MAOA gene interaction. The TPH2 gene plays an important role in the ASPD incidence. The negative of the home environment may further aggravate the adverse impact on the individual carrying the risk genotype or haplotype the higher individual ASPD susceptibility.

Related Dissertations

  1. Polymorphisms of Y-STRs in Uygur and Kazak Ethnic in Xinjiang,R394
  2. The Effects of Family Environment on Aggressive Behavior of Children in PE Course,G623.8
  3. Children with acute leukemia also prototype folate carrier gene polymorphism,R733.71
  4. Studies on Family Environment Factors and Brain Imaging of Phonological Activation with Chinese Dyslexic Children,R749.94
  5. Genetic Polymorphisms of XPA、XPC and XRCC1 Are Correlated with the Prognosis of Non-small-cell Lung Cancer Patients Treated with Platinum-based Chemotherapy,R734.2
  6. Associaction between MAFB,IRF6,8q24 and 10q25 Polymorphisms and Nonsyndromic Cleft Lip with or Without Cleft Palate in Southern Han Chinese,R782.2
  7. The Association between cPLA2 Genetic Polymorphism and Alzheimer’s Disease in Hunan Han Population of China,R749.16
  8. Association of miRNA-146a and EPHX2 Polymorphisms with Risk of Ischemic Stroke in Changsha Han Population and the Mechanisms,R743.3
  9. The Study of Association between Clock Gene T3111C and T257G Polymorphisms and Sleep Epilepsy in a Hunan Han Population,R742.1
  10. Study on Association between Single Nucleotide Polymorphisms of PATZ1 Gene as Well as DNMT3L Gene and Azoospermia,R698.2
  11. Association Analyses between FOXO1, HNF4A and ADRA2A in Glucose Metabolism and Type 2 Diabetes,R587.1
  12. Polymorphism Study of Tumor Necrosis Factor Alpha (TNF-α) in Dermatomyositis Patients,R593.26
  13. Xinjiang Uygur interleukin- 13 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease association studies,R563.9
  14. Association of Genetic Polymorphism in Brain Natriuretic Peptide with Essential Hypertension in Hunan Han,R544.1
  15. Correlation between Coronary Artery Disease and the Level of Serum Lectin-like Oxidized Low-density Lipoprotein Receptor-1 and Its Polymorphism,R541.4
  16. Polymorphism of Killer Cell Immunoglobulin-like Receptors Gene in Sichuan Han Population, China,R394
  17. Study of Population Genetic Structure of House Mouse MUS MUSCULUS CASTANEUS in Shanghai,Q953
  18. Application of Allele-specific PCR in SNP Differentiation and Ferritin Nanoparticle Chemiluminescence Determination,TB383.1
  19. Screening and Characterization of Probiotic Lactobacillus Strains with Inhibitory Activity to Monoamine Oxidase,TQ460.1
  20. Study on 24 SNPs in the Coding Region of Human mtDNA in Wuhan Han Population,D919
  21. The MRNA Expression of Secretoglobins (SCGB) in Chronic Rhinosinusitis and Their Cytokine-driven Expression Reglulation,R765

CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Personality disorder
© 2012 www.DissertationTopic.Net  Mobile