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Association Study of Genetic Polymorphisms in Serotonin System and Family Environment with Antisocial Personality Disorder

Author: WuYanFeng
Tutor: TanZuoAn
School: Nanjing Medical University
Course: Psychiatry and Mental Health
Keywords: Antisocial Personality Disorder 5-HT transporter Monoamine oxidase A Tryptophan hydroxylase 2 Family environment Impulsive behavior Single nucleotide polymorphisms Haplotype
CLC: R749.91
Type: Master's thesis
Year: 2011
Downloads: 68
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Abstract


Purpose of Antisocial Personality Disorder (Antisocial personality disorder, ASPD) role is well received by the occurrence of genetic factors, but also by environmental factors. This study is to determine the 5-HT transporter (5-Hydroxytryptamine transporter 5-HTT) and monoamine oxidase A (Monoamine oxidase A, MAOA) and tryptophan hydroxylase 2 (Tryptophan hydroxylase2, TPH2) gene 5 - hydroxytryptamine (5 -Hydroxytryptamine ,5-HT) system candidate genes for each mutant single nucleotide polymorphisms (Single nucleotide polymorphism, SNP), to explore the frequency of the mutant allele, genotype frequencies and haplotypes in patients and control groups The difference between the 5-HTT and MAOA gene interaction between, TPH2 gene family environment, to detect genetic markers of ASPD and its possible pathogenesis. Method ASPD 117 patients were male, aged 20-52 years old, the average age (31.31 ± 6.27) years; healthy control group, 142 cases were male, aged 20-50 years old, average age (32.81 ± 7.57) years old. Variable number of tandem repeats (Variable number of tandem repeats, VNTR) and polymerase chain reaction - restriction fragment length polymorphism (Polymerase chain reaction-restriction fragment length polymorphism, PCR-RFLP) assay 5-HTT, the MAOA rs1137070 and TPH2 rs4570625, rs4131347, rs4290270, rs7305115 gene polymorphism; using the Barratt Impulsiveness Scale (Barratt, Impulsiveness Scale-11, BIS-11) and the Family Environment Scale - Chinese version (Family Environment Scale-Chinese Version, the FES- CV) assessment impulse level and family environment; using SHEsis Software analysis TPH2 gene haplotypes. 1, the patient group BIS-11 total score, pay attention to factors and unplanned factor score was significantly higher (P lt; 0.05). Emotional expression of the patient group scored lower than the control group, contradiction success controlling score higher than that of the control group, the difference was statistically significant (P lt; 0.05). 2,5-HTTVNTR, MAOA rs1137070 genotype distributions are in line with the genetic balance law of (Hardy-Weinberg equilibrium, HWE), allele and genotype frequencies between the patient and control groups showed no significant sex; 5-HTT and MAOA gene polymorphism exists interaction. TPH2 rs4570625, rs4131347, rs4290270, rs7305115 each SNP genotype distribution are in line with HWE. rs4570625 genotype and allele frequencies between ASPD group and the control group the differences were statistically significant. The strength of the association analysis showed ASPD and GG genotype was positively associated [odds ratio (OR) = 1.458, 95% confidence interval (CI) = 1.080-1.968), with the G allele has also become a positive association (OR = 1.479,95% CI = 1.045-2.094). The other three-locus genotype and allele frequency distribution ASPD group and the control group, the difference was not significant. 4, TPH2 rs4290270 and rs7305115 allele pairing was haplotype TA, ASPD frequency was significantly higher than that of the control group, the difference was significant (χ to 2 = 6.177, P lt; 0.05), OR value of 1.865,95% CI as 1.135-3.065. Other haplotypes were no differences between the two groups was significant. 5, in accordance with the TPH2 rs4570625 genotype the ASPD patients BIS-11 score divided into three groups, with ASPD patients with GG genotype group BIS-11 total score and factor scores were (71.28 ± 7.50) min, (19.60 ± 3.41 ) points, (25.73 ± 4.92) min (25.95 ± 4.77) min] were higher than the GT genotype [(66.23 ± 8.06) points, respectively, (17.79 ± 3.02) min, (23.06 ± 3.84) min, (25.38 factor, motility factor and the difference was statistically significant (F lt; 0.05), and unplanned factor was no significant difference. Carrying G allele Group BIS-11 total score and factor scores [were (68.52 ± 8.17) points, (18.61 ± 3.31) min, (24.27 ± 4.54) min, (25.64 ± 4.86) min] were higher than those do not carry 6, according to whether TPH2 rs4570625 T allele genotype were divided into two groups (rs4570625T rs4570625T-group), expression of emotion in the family environment, success, morality, religion, and there is an interaction of four factors and TPH2 rs4570625 controlling role (P lt; 0.05), OR values ??were 1.122,0.843,1.080 0.880,95% CI of 1.043-1.206,0.747-0.951, 1.010-1.155 and 0.792-0.978. Emotional expression in the family environment, the TA haplotype Moral Religion 2 factor paired with the TPH2 rs4290270 and rs7305115 allele interaction (P lt; 0.05), the OR values ??were 1.122 and 1.080,95% CI 1.043-1.206 and 1.010-1.155. Conclusion 5-HTT, MAOA gene polymorphism with ASPD was no significant correlation ,5-HTT and MAOA gene interaction. The TPH2 gene plays an important role in the ASPD incidence. The negative of the home environment may further aggravate the adverse impact on the individual carrying the risk genotype or haplotype the higher individual ASPD susceptibility.

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