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Background stroke fatigue (post stroke fatigue, PoSF) is common after stroke symptoms, the incidence of 39% -72%, POSF stroke patients suffering can lead to serious consequences, the degree of recovery and the patient's limb function, ADL level and reduction in quality of life related, and may be associated with a high mortality rate, more and more people's knowledge and awareness, research shows that fatigue after stroke mechanism and the body's inflammatory factor IL-1beta, TNF-a and IL-6 related comprehensive rehabilitation therapy and traditional Chinese medicine decoction flavored Bu Yang Huan Wu Tang fatigue improve after a stroke effectiveness of pharmacological studies of Chinese proprietary IL-1beta, TNF-a and the L-6 and other related PoSF inflammatory factors there is a change, but the lack of Modified Bu Yang Huan Wu Tang with modern rehabilitation PoSF evidence of inflammatory cytokines in serum, so that the treatment of post-stroke fatigue remain on the level of experience. Objective on flavored Bu Yang Huan Wu Tang with a modern comprehensive rehabilitation the intervention PoSF, observe the clinical efficacy and serum inflammatory mediators change, and to explore the relationship between PoSF serum inflammatory mediators, to explore more effective Integrative Medicine fatigue after stroke treatment. Method 1. GENERAL INFORMATION to January 2010 to January 2011, was admitted to a hospital in Guangdong Provincial Hospital of rehabilitation treatment of patients in this study. 70 cases were randomly divided into a treatment group (rehabilitation medicine) and control group (only rehabilitation), 35 cases in each. Methods This study used a randomized controlled design method for research. Patients met the inclusion criteria were randomly divided into treatment group and control group. All patients were recovered comprehensive training, the treatment group taking flavored Bu Yang Huan Wu Tang, before treatment and 30 days after each rating fatigue VAS, FSS, MBI conducted, and the determination of plasma IL-1beta, TNF-a and IL-6 concentration, according to the VAS, FSS, MBI score to determine the clinical efficacy, and observe the inflammatory factor to change the situation. In addition, the two groups before and after treatment are receiving liver and kidney function, three conventional record the adverse effects of the treatment process, in order to evaluate the safety of the two treatment methods. Data were analyzed by t-test and chi-square test. Results All 70 patients in the result, no death and shedding. Two groups of patients after 30 days of treatment, the treatment group in fatigue VAS, FSS, the MBI than the control group with statistically significant differences (P lt; 0.05), serum IL-1beta, TNF-a and IL-6 difference is also significant (P lt ; 0.05) and serum IL-1beta, TNF-a and IL-6 changes with VAS FSS score was positively correlated with the MBI index was negatively correlated. Conclusion This study showed that the treatment group and the control group after 30 days of treatment, can reduce fatigue in patients after a stroke FSS score, fatigue VAS score, improve MBI index score; reduce serum IL-1beta, TNF-a and IL-6 levels. The treatment group was significantly better than the control group. Description Modified Bu Yang Huan Wu Tang combined with comprehensive rehabilitation measures can significantly improve fatigue in patients with post-stroke fatigue index, activities of daily living, and serum levels of inflammatory factors, serum levels of inflammatory factors the fatigue of ADL in patients with stroke negative factor.
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