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Purpose of myasthenia gravis (MG) is an autoimmune disease, pathogenic site in the neuromuscular junction, can selectively cause muscle fatigue phenomenon, for most of the cases, the immune attack target is skeletal muscle acetylcholine receptors. Approximately half of the patients in the initial symptoms of MG ptosis, diplopia, many people from the pure ocular myasthenia gravis (OMG) to generalized myasthenia gravis (GMG) progress, the patient hopes non-drug treatment and biliary alkali esterase inhibitors, but ultimately still have to oral corticosteroids or immunosuppressants to control the disease progresses, OMG pathogenesis is not clear up to now. Regulatory T cells in the control and balance of the immune response, immune tolerance mechanisms to maintain a significant role. OMG which may affect the important influence factors. This study explores the impact of adult clinical outcomes OMG factor. Methods January 2004 -2009 in March in our clinic and ward diagnosed in patients with ocular myasthenia weakness of 148 patients with newly diagnosed time as a starting point, OMG progression to GMG time as an endpoint, progression group 74 patients, 67 patients at the end of the follow-up is still the ocular myasthenia gravis. Aged 14-72 years, mean (38.81 ± 14.62) years; follow-up period, seven patients were lost to follow-up, this study measured by flow cytometry in peripheral blood CD4 ~ CD25 ~ regulatory T cells accounted for the percentage of CD4 ~ T cells . Demographic characteristics (gender, age), with or without thymoma or thymic hyperplasia and thymus are not completely degraded, plus hormones and steroids or immunosuppressants, CD4 ~ CD25 ~ regulatory T cells accounted for the proportion of CD4 ~ cells as a self- variables into ocular myasthenia gravis systemic time as the dependent variable for Cox regression analysis. Results Cox regression analysis showed that: immunosuppressive agents [95% CI (0.25-0.96) P = 0.038] and CD4 ~ CD25 ~ cells accounted for CD4 ~ cell ratio [95% CI (0.73-0.91), p lt; 0.01] which two variables, CD4 ~ CD25 ~ regulatory T cells accounted for the greater proportion of CD4 ~ cells, used in the treatment or the addition of immunosuppressive agents, ocular myasthenia gravis, systemic risk of progression to the smaller of these two variables are transformed ocular myasthenia gravis protective factors. CD4 ~ CD25 ~ cells accounted for the proportion of CD4 ~ cells in ocular myasthenia gravis and systemic progression of time, the partial correlation coefficient 0.567 (p lt; 0.05), representing a significant correlation between the two. Conclusion: CD4 ~ CD25 ~ regulatory T cell defects is an important aspect of the pathogenesis of MG, the OMG in patients, regulatory T cells have a strong immune against nature, in some OMG relatively small number of patients or functional defects problems, which can be the cause progress at the OMG. In addition, the immunosuppressant may prevent the progression of OMG to GMG protective factors.
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