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Objective: A retrospective analysis of Japanese encephalitis (epidemic encephalitis B, Japanese encephalitis, referred to as \Method: 1. Collection Children's Hospital of Chongqing Medical University in 2010 admitted 108 patients met the inclusion criteria of the Japanese encephalitis in children with clinical data and analyzed retrospectively; 2 at least four months after hospital discharge follow-up, the use of Liverpool prognosis score sheet (Liverpool Outcome Score) The prognosis is divided into Ⅰ ~ Ⅴ grade (Ⅰ level of death, Ⅱ grade have serious consequences that can not live independently, Ⅲ grade with moderate sequelae but basically to live independently, Ⅳ grade mild sequelae can independent living, Ⅴ level is healed), assess the prognosis of this group of epidemic encephalitis B cases; 3 would prognostic classification of grade Ⅰ ~ Ⅱ in children classified as poor prognosis group, Ⅲ ~ Ⅴ grade children classified as good prognosis group to explore the clinical indicators (age, sex, JE vaccination history, the initial duration, level of consciousness, convulsions times, respiratory failure, upper gastrointestinal bleeding, cerebrospinal fluid white blood cell count and CSF protein content) and prognosis relationship. Results: The group of 108 infants, onset time were from July to September, the age of onset in the two months to 15 years old, 2 to 6 age group of the children up (54.6%), the vast majority of children from rural areas (91.7%), with only 18 cases (16.7%) in children vaccinated with JE vaccine. Clinical manifestations, all patients had fever and varying degrees of consciousness, fever with high fever (80.6%) based, 82 cases (75.9%) have convulsions occurred in 7 cases (6.5%), respiratory failure, 24 cases ( 22.2%) of upper gastrointestinal bleeding. Laboratory tests, 68 patients (63.3%) showed blood leukocyte. 94 routine cerebrospinal fluid examination in children, elevated CSF white blood cell count has 60 cases (63.8%), elevated CSF protein content with 43 cases (45.7%). Cranial imaging was higher (68.9% cranial MRI, CT 52.9%), mainly as thalamus and basal ganglia dominated by abnormal signal; EEG positive rate of 97.9%, mainly as a wholly diffuse brain δθ increased activity. 72 cases of successful follow-up children, seven cases (9.7%) died, four cases (5.6%) had severe sequelae, 6 cases (8.3%) had moderate sequelae, 13 cases (18.1%) had mild sequelae, 42 cases (58.3%) healed. After classification, prognosis group consisted of 11 cases of children (15.3%), good prognosis group consisted of 61 cases of children (84.1%). The statistical analysis showed that the initial duration, level of consciousness, convulsions times, respiratory failure and upper gastrointestinal bleeding related to prognosis. Conclusion: The group of 108 cases of Japanese encephalitis in children with clinical features consistent with the general characteristics of children JE; successful follow-up of 72 cases of children with poor prognosis results suggest a higher incidence of Japanese encephalitis (15.3%), attention should be paid ; initial duration, level of consciousness, convulsions times, respiratory failure and upper gastrointestinal bleeding is an important prognostic factor affecting JE. Initial shorter the duration, the deeper level of consciousness, convulsions more frequent occurrence of respiratory failure and (or) with upper gastrointestinal bleeding often prompts a poor prognosis.
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