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The Influence of Sevoflurane in Various Duration on Recovery from Neuromuscular Block Following a Single Bolus Dose of Cisatracurium in Children

Author: XuBinBing
Tutor: YeMao
School: Chongqing Medical University
Course: Anesthesiology
Keywords: Children Cisastracurium Sevoflurane Neuromuscular block Recovery
CLC: R726.1
Type: Master's thesis
Year: 2011
Downloads: 18
Quote: 0
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Abstract


Objective To study the effects of 1 MAC sevoflurane of different durations on the recovery from neuromuscular block following a single bolus dose of cisatracurium in children.Mthods 60 children（28yr, ASAⅠⅡ） undergoing elective surgery were randomly divided into 3 groups, （20 children each）, according to difference, duration of inhalation of sevoflurane: 30-min sevoflurane(group S30), 60-min sevoflurane(group S60), or total intravenous anesthesia(（i.e. no sevoflurane, group T）. Anesthesia was induced with midazolam, propofol and sufentanyl, a single bolus dose of cisatracurium (3ED95, 0.15mg·kg-1). Anesthesia was maintained with remifentanil and propofol in all groups, meanwhile, Group S30 and S60 children were exposed to 1 MAC sevoflurane after tracheal intubation. Neuromuscular block was assessed with TOF-Watch SX accelerometry. Onset time, duration of peak effect, recovery index, duration of clinical action, duration of total action and time to TOFR（T4/T1） 70% were recorded. Results There was no significant difference in onset time among the three groups（P>0.05）. Duration of peak effect, duration of clinical action, duration of total action and TOFR0.7 were significantly prolonged with increasing durations of sevoflurane inhalation （P<0.05）. Recovery index of Group S60 was significantly prolonged compared to Group T （P<0.05）, while recovery index of Group S30 was not significantly different from Group T and Group S60 （P>0.05）.Conclusion The muscle relaxation effect of cisatracurium was potentiated by 1MAC sevoflurane with increasing durations of inhalation in children. 60 min of sevoflurane inhalation may delay the spontaneous recovery from a single bolus dose of cisatracurium, while 30 min or less of sevoflurane may not.

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CLC: > Medicine, health > Pediatrics > Pediatric surgery > Pediatric surgery and surgical
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