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Background: Currently, individuals with certain genetic susceptibility of inflammatory bowel disease (inflammatory bowel disease, IBD) is due to congenital and (or) acquired causes of intestinal symbiotic microbes due to the inappropriate immune response intestinal lesions as an early manifestation of chronic systemic disease of the immune system [1,2]. Mainly includes ulcerative colitis (ulcerative colitis, UC) and Crohn's disease (Crohn's disease, CD). The prevalence of UC and CD 4.0/10 million to 44.3/10 and 3.6/10 to 7.7/10 million, respectively. IBD good age two peaks in 15-year-old and 30-year-old children's group is fairly limited information. With the development of the laboratory tests, endoscopic technology, children's groups IBD diagnosis rate has been significantly improved, epidemiology, clinical data about the group of inflammatory bowel disease in children are to be supplemented, children's group of IBD diagnosis and treatment still need further clinical studies. Objective: This study aimed at the children's group of clinical signs and symptoms of inflammatory bowel disease, laboratory tests, endoscopy and histopathology, as well as the diagnosis and treatment of statistical analysis, summarize a group of inflammatory bowel disease in children Clinical characteristics and Clinic experience. Subjects and methods: an object: collection of Chongqing Medical University Children's Hospital from December 2000 to December 2010 and 10 years all discharge diagnosis the considerations of IBD cases data; Digestive Diseases Society standards developed with reference to the Chinese Medical Association in 2001, preliminary data further audit; This paper analyzed cases meet the diagnostic criteria, and a brief summary of the suspected cases. 2 methods: retrospective analysis of the cases included in the study, and to further children clinical treatment and therapy by telephone, mailing, follow-up letter, and on-site follow-up. 3: Statistical analysis of children grouped according to the clinical data, further use of the Microsoft Office Excel2003 and statistical software SPPS18.0 for statistical analysis. Count data using Fisher's exact test, measurement data to the median (M), and the range of; two mean difference between the two-sample t-test, P lt; 0.05 statistically significant. Results: abdominal pain, diarrhea, bloody diarrhea and fever, anemia, joint disease, oral ulcers and other inflammatory bowel disease intestinal performance and extra-intestinal manifestations; subject to the limit of the number of cases, in terms of clinical symptoms, the study did not confirm the UC group The difference between the CD group (P gt; 0.05). Commonly used clinical laboratory tests white blood cell count, hemoglobin, serum albumin, platelet count, C-reactive protein, erythrocyte sedimentation rate, immunoglobulin IgG in UC group and the CD group found no significant differences (P gt; 0.05). The involvement of the distal colon of UC group was significantly more than the CD group (P = 0.027), and upper gastrointestinal involvement (P = 0.028), the jejunum and ileum or terminal ileum and ileocecal involvement (P = 0.002) in the CD group was significantly higher than the UC group common, having statistically significant difference. Histological examination positive rate cut specimens drawn in endoscopic surgical technique. Conclusion: Children group of inflammatory bowel disease mainly include abdominal pain, diarrhea, blood in the stool, fever, anemia, joint disease, oral ulcers, etc.. The blood analysis, C-reactive protein, erythrocyte sedimentation rate is an important laboratory tests of disease activity monitoring inflammatory bowel disease. Endoscopy plays an irreplaceable role in the diagnosis of inflammatory bowel capsule endoscopy in children group should further promote the inflammatory bowel disease through aggressive treatment, better results but large individual differences.
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