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Reparative Effect of Mesenchymal Stem Cells on Immunization-induced Injury of the Ovaries in Mice

Author: LiWeiNa
Tutor: XieZuoZuo
School: Jinan University
Course: Developmental Biology
Keywords: Bone marrow mesenchymal stem cells Ovarian Immunity Damage Repair
CLC: R711.75
Type: Master's thesis
Year: 2011
Downloads: 28
Quote: 0
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Abstract


Objective: To investigate the mouse bone marrow mesenchymal stem cells (MSCs) transplantation repair and its mechanism of immune damage the ovaries . Method :6 -8 -week-old wild-type health ICR female mice were randomly divided into four groups , each group of 12 . A , group B intraperitoneal injection of adjuvant as a control , C, D group the pig ovarian protein active immunization immune damage ovarian model . Latter group B , D group were transplanted bone marrow MSCs from GFP transgenic mice of group A, C injection volume of PBS . MSCs transplantation, the mice were killed according to the established time HE staining of ovarian tissue sections , TUNEL analysis of apoptosis , while taking advantage of Realtime PCR detection of ovarian and immune organs of IFN-γ and IL-4 expression levels . Results: abdominal transplantation MSCs can reach the mouse immune organs and ovarian ; of MSCs transplantation can promote the the immune injury ovary tissue repair ; the immune injury ovary apoptosis of granulosa cells was significantly reduced after transplantation of MSCs , ovarian IFN-γ/IL-4 decline . Conclusion : MSCs transplantation can promote immune ovarian damage repair mechanism may reduce the granulosa cell apoptosis , down the IFN-γ/IL-4 of ovarian .

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CLC: > Medicine, health > Obstetrics and Gynaecology > Gynecology > Other diseases of the female genital > Ovarian disease
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