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Experimental Study of Low-energy Shock Waves in Microfracture Holes in the Repair of Articular Cartilage Defects in a Rabbit Model

Author: WangZuo
Tutor: LiZhongLi
School: PLA Postgraduate Medical School
Course: Surgery
Keywords: Joint Cartilage repair Bone marrow stimulation techniques Shock wave
CLC: R687.3
Type: Master's thesis
Year: 2011
Downloads: 54
Quote: 0
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Abstract


Research purposes of New Zealand white rabbits were full-thickness articular cartilage defect model application microfracture surgery and microfracture hole application of low-energy shock wave treatment, observation and analysis repairing effect. Clear microfracture hole application of low-energy shock wave effect of the possibility of improving the model of New Zealand white rabbits cartilage repair, explore a new improved micro-fracture surgery. Research Methods 36 adult New Zealand white rabbits were randomly divided into three groups. The establishment of New Zealand white rabbits knee femoral condyle full-thickness cartilage defect model. After the application of micro-fracture surgery treatment of the shockwave joint microfracture surgery treatment group, the application pressure ballistic shock wave treatment instrument endoscopic probe (diameter 0.8mm) shock wave therapy (energy flux density 0.095mj / microfracture holes (diameter 1mm) mm2, 200 shocks). Microfracture surgery treatment group the only application microfracture surgery treatment. Articular cartilage defects of the blank control group not be any treatment. 4, 8 and 12 weeks after surgery to repair the results of the gross appearance, histological and immunohistochemical assessment and application histological scoring system for histological evaluation of repair results, the results were statistically analyzed. Findings 12 weeks after the shock wave joint microfracture surgery treatment group and the microfracture surgery treatment group cartilage defect gradually repair tissue filling the blank control group, no cartilage defect repair tissue formation. Four weeks after histological staining and immunohistochemical staining shockwave joint microfracture surgery repair the results of the treatment group and the microfracture surgery treatment group no significant difference between 8 and 12 weeks after histological staining and immunohistochemical staining shock wave combined with micro fractures in the treatment group repair tissue than microfracture surgery therapy group containing chondrocytes proteoglycan and type II collagen, microfracture hole at the bottom of angiogenesis. After 8 weeks, 12 weeks microfracture surgery treatment group defect repair fibrous tissue within the organization to generate and gradually increased. Wakitani histological scores shockwave joint microfracture surgery treatment group after 8 weeks, 12 weeks of repair is better than the microfracture surgery therapy group (P lt; 0.05). Conclusion microfracture surgery, microfracture hole application of low-energy shock wave treatment of New Zealand white rabbits knee full-thickness cartilage defect repair is better than the simple application of micro-fracture surgery. The shock wave method for joint microfracture surgery the microfracture surgery new ways to repair articular cartilage damage effect is an improvement.

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CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Orthopedic surgery and surgery > Bone surgery
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