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Tetrahydropyridine compounds with good biological activity, in the biomedical and organic synthesis has a wide range of applications . Thus , synthesis of structural units of the formula tetrahydropyridine gradually become a hot research pharmaceutical and organic chemistry . Multicomponent reactions (MCRs) with high efficiency , diversity , complexity, atom economy and environmental friendliness can achieve rapid synthesis of large numbers of structural diversity and complexity of the compound and establish appropriate compound libraries , thus causing a chemical family concerns. In recent years, the literature on MCRs rapid growth in the number of new MCRs constantly being discovered , MCRs in drug discovery , chemical pesticides and other aspects of total synthesis of natural products widely used . In recent years, our group in the use of multi-component reaction synthesis of various heterocyclic compounds has achieved remarkable results. This paper discusses the use of multi-component reaction to synthesize multi-substituted 1,2,3,4 - tetrahydropyridine derivatives research . In this paper, α- acetylenic ketones, amines , active methylene compounds and aldehydes in the L-proline -catalyzed achieve a one-pot multicomponent reactions. The reaction of the amine hydrogen successively through the process , Prins reaction , Mannich reaction , intramolecular dehydro - cyclization process , to obtain a series of different substituents containing 1,2,3,4 - tetrahydro- pyridine derivative . In addition, ferric chloride, L-proline of the catalyst, the α- acetylenic ketone to replace ethyl acetoacetate , can also occur in the four-component reaction of another series of 1,2,3,4 - tetrahydropyridine derivatives. Then we selective expansion of the substrate , a total synthesis of 22 1,2,3,4 - tetrahydro- pyridine derivative , wherein the compound of the molecular structure of 5baa single-crystal X-ray diffraction method to determine . The synthesis method uses a cheap , easy to get catalyst and substrate , easy to operate , easy to implement structural diversity of substrates with high atom economy and environmental friendliness, as polysubstituted 1,2,3,4 - tetrahydropyridine derivatives provides a convenient path and adapt to the development trend of green chemistry and requirements.
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