Dissertation > Excellent graduate degree dissertation topics show

Application and Preparation of Polysaccharide-based Semi-IPN Hydrogels

Author: CaoMengJie
Tutor: ZhaoSanPing
School: Wuhan Textile University
Course: Textile Material and Textiles Design
Keywords: Semi- interpenetrating network hydrogel Chitosan Sodium alginate β-cyclodextrin Drug release Dye adsorption
CLC: O648.17
Type: Master's thesis
Year: 2011
Downloads: 83
Quote: 0
Read: Download Dissertation

Abstract


Polyethylene glycol (PEG) as initiator and stannous octoate (Sn (Oct) 2) as catalyst, initiator ε-caprolactone monomer (ε-CL) ring-opening polymerization of water-soluble PCL-PEG-PCL triblock The block copolymer, and then with glycidyl methacrylate (GMA) obtained by reacting a photopolymerizable biodegradable macromer. N-isopropyl acrylamide (NIPAAm), chitosan (CS) or sodium alginate (AG), PCL-PEG-PCL macromer and the amount of photo-initiator to the aqueous solution of low density UV irradiation, the original bit fast formation of PNIPAAm / CS or the PNIPAAm / AG semi-interpenetrating network hydrogel. PNIPAAm / CS semi-interpenetrating network hydrogel system to study the swelling properties of the hydrogels in different temperatures and different pH and shock swelling - eliminate swelling properties, the results show that the semi-interpenetrating network hydrogel with temperature and pH sensitive , and this stimulus-response having good reversibility. With bovine serum albumin (BSA) as a model drug, the release pattern of the drug-loaded gel in vitro studies results show that at 37 ℃ percentage cumulative release of BSA, in a buffer solution of pH2.0 than at pH7.4 phosphorylation buffer solution high. While PNIPAAm / AG semi-interpenetrating network hydrogel has a temperature and salt sensitivity, and showed good reversibility. The introduction of the hydrogel alginate accelerate the rate of release of BSA. Chitosan and sodium alginate as a semi-interpenetrating structure is introduced into the network structure of the hydrogel, not only gives the hydrogel stimuli-responsive, such as pH sensitivity (CS) and a salt thereof the sensitivity (AG), and of polysaccharide introduced able significantly improve the mechanical properties of the hydrogel. Under strong alkaline conditions, epichlorohydrin crosslinked toluene-β-CD inclusion compound of a water-soluble linear β-cyclodextrin polymer (CDP), and then react with GMA can be prepared photopolymerizable the CDP molecular monomers. CDP macromer as crosslinker, in CS or the AG solution, and the acrylamide monomer (AAm) or the NIPAAm monomer by UV polymerization prepared separately the CDP / PAAm / CS and the CDP / PNIPAAm, / AG semi interpenetrating network hydrogels. Detailed study of the CDP / PAAm / CS semi-interpenetrating network hydrogels on the adsorption capacity of anionic dyes Acid Scarlet (AR 18) investigated the content of chitosan gel formulations CDP amount of crosslinking agent, dye pH value ambient temperature oscillation rate, the amount of hydrogel and dye initial concentration on semi-interpenetrating network hydrogel dye adsorption. The results showed that the semi-interpenetrating network hydrogel dye adsorption capacity increases with the chitosan content, oscillation rate and the increase in the initial concentration of the dye; With the the dye pH value, temperature increases and reduce. The adsorption process pseudo second-order equation and the Langmuir isotherm equation. The semi-interpenetrating network hydrogel adsorbent material for anionic dyes. CDP / PNIPAAm / AG semi-interpenetrating network hydrogel system, examine the content of sodium alginate, the ambient temperature, the dye solution ionic strength, the initial concentration of the dye type and put into gel content and other factors on the cationic dye A base violet (MV) adsorption capacity. The results show that the adsorbents of the hydrogel can be used as a cationic dye. Polysaccharide-based semi-interpenetrating network hydrogel cyclodextrin components of the package of dye molecules strengthen the gel and the combined effects of ion complex role of ionic groups in the hydrogel network with ionic groups of the dye molecules on the adsorption capacity of the dye molecules.

Related Dissertations

  1. Studies on Chitosan and Its Derivatives Adsorption for Paralytic Shellfish Poisoning in Ostrea Rivularis Could,TS254.4
  2. Thermal Stability of Complexes of Chitosan Quaternary Ammonium Salt and Metal Ion,O634
  3. Polyethylenimine Conjugated Stearic Acid-g-chitosan Oligosaccharide Micelles for Antitumor Gene Therapy,R450
  4. Improvement of Preparation Technology for Chitin and Chitosan from By-product of Litopenaeus Vannamei,TS254.9
  5. Biological Control of Meloidogyne Spp. in Cucumber (Cucumis Sativus L.) and Development of the Ecological and Environment-friendly Fertilizer with Pesticides,S436.421
  6. Molecular Recognition Based on β-cyclodextrin and Chemical Modified β-cyclodextrin as Receptor,O636.12
  7. Studies on the Dissolution of Chitosan in Ionic Liquids,O636.1
  8. Application Adipose-devired Stem Cells and Silk Fibroin and Chitosan Scaffold Materials Building Common Cells-stents Complex Experiments,R329
  9. Bovine serum albumin and protamine from NOCC / alginate hydrogels release : the isoelectric point of two different biological molecules controlled trial,R943
  10. Alginate - chitosan membrane in guided bone regeneration in applied research,R318.08
  11. Cyclodextrin -modified magnetic nanoparticles synthesis and study drug carrier,TQ460.1
  12. Preparation and Evaluation of Thermosensitive Nanocarrier,R943
  13. Study on the Hemostatic Effect of Carboxymethly Chitosan and its Safety in the Blood System Evaluation,R318.08
  14. Mitomycin - modified chitosan sustained-release preparation of the diaphragm , nature and biological evaluation,R779.6
  15. bFGF chitosan microspheres and promote Schwann cell proliferation studies,R651.2
  16. Experimental Study on the Compatibility between Chitosan-gelatin Scaffold and Synovium-derived Mesenchymal Stem Cells from Human,R318.08
  17. Effect of AMSCs Compound Chitosan/Gp/collagen Ⅰ Transplantation on TNF-α 、IL-1β Content in Early Degenerated Intervertebral Disc of Rabbit,R681.53
  18. Preparation and Application of Modified Chitosan Complex Flocculant,P747
  19. Preparation of Fe3O4 and Fe3O4 / Chitosan Nanocomposite Induced by Static Magnetic Field,TB383.1
  20. Preparation and Application of Modified Chitosan Magnetic Microscopic Particles,O636.1
  21. Properties and Preparation of GSH-sensitive Polymeric Prodrug: 6-Mercaptopurine-Carboxymethyl Chitosan,TQ463.2

CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Colloid chemistry ( physical and chemical dispersion system ) > Colloid > Gel and soft
© 2012 www.DissertationTopic.Net  Mobile