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Studies on Quality Control of Tibetan Medicine Herba Pterocephali

Author: TanDe
Tutor: ZhangYi
School: Chengdu University of Traditional Chinese Medicine
Course: Medicinal Chemistry
Keywords: Tibetan medicine herba pterocephali quality control loganin HPLC
CLC: R284
Type: Master's thesis
Year: 2011
Downloads: 93
Quote: 0
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Abstract


Herba pterocephali is the whole plant of Pterocephalus hookeri (C. B. Clarke) Hoeck, one of the dipsacacea species. It shows the effects of detoxification, removing fever and controlling the diarrhoea, supporting health and relieving arthralgia. TLC was used to identity the ursllic acid in Pterocephphali herba, and the content of ursolic acid and oleanolic acid were determined by HPLC in《China pharmacopoeia》(2010 S’). Previous research had suggested that the existing quality standard of pterocephali herba should be supplement.Objective:To improve the quality standard of the herba pterocephali.Methods:Using TLC to identify the loganin in herba pterocephali; Using spectrophotometry to determine the iridoid glycosids of herba pterocephali; HPLC is used to determine the loganin; optimizing the determination method of oleanolic acid and ursolic acid by adding muriatic acid during the extraction.Results:1 Established TLC method to identify the loganin in herba pterocephali.2 Established method to determine the total iridoid glycosids of herba pterocephali by spectrophotometry. The average content of total iridoid glycosids of herba pterocephali is 7.76%, and the bottom line is set as 6%.3 Established HPLC method to determine the loganin in herba pterocephali and and the bottom line is set as 0.01%.4 Optimized the determination method of oleanolic acid and ursolic acid by adding muriatic acid during the extraction. The average content of oleanolic acid is 1.00%, the average content of ursolic acid is 0.25%,and the bottom line of oleanolic acid and ursolic acid is set as 1.0%.Conclutions: 1 Complementing the method for the identification and determination of iridoid glycosids to contribute to the quality control of herba pterocephali.2 Comparisons are made to found that the determination of oleanolic acid and ursolic acid of herba pterocephali by adding muriatic acid during the extraction should be more reasonable for its quality control.

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